Rabbit Anti-SLC39A7 Recombinant Antibody (CBXS-0473) (CBMAB-S3423-CQ)

Name: Rabbit Anti-SLC39A7 Recombinant Antibody (CBXS-0473)
SKU: CBMAB-S3423-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

CBXS-0473

Application

WB, IP

Specificity

Human, Mouse

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Solute Carrier Family 39 Member 7

Introduction

The protein encoded by this gene transports zinc from the Golgi and endoplasmic reticulum to the cytoplasm. This transport may be important for activation of tyrosine kinases, some of which could be involved in cancer progression. Therefore, modulation of the encoded protein could be useful as a therapeutic agent against cancer. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

Human	7922
Mouse	14977

UniProt ID

Human	Q92504
Mouse	Q31125

Alternative Names

Solute Carrier Family 39 Member 7; Solute Carrier Family 39 (Zinc Transporter), Member 7; HLA Class II Region Expressed Gene KE4; Really Interesting New Gene 5 Protein; Histidine-Rich Membrane Protein Ke4; Zrt-, Irt-Like Protein 7; RING5; HKE4;

Function

Zinc transporter, that transports Zn2+ from the endoplasmic reticulum/Golgi apparatus to the cytosol. Transport is stimulated by growth factors, such as EGF, and Ca2+, as well as by exogenous Zn2+. Has an essential role in B cell development and is required for proper B cell receptor signaling (PubMed:30718914).

Biological Process

Biological Process B cell differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular zinc ion homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process zinc ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Endoplasmic reticulum membrane
Golgi apparatus, cis-Golgi network membrane

Involvement in disease

Agammaglobulinemia 9, autosomal recessive (AGM9):
A form of agammaglobulinemia, a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.

PTM

Rapidly phosphorylated by CK2 following Zn2+ treatment. This phosphorylation is required for efficient cytosolic Zn2+ release.
Methylation at some His residue by METTL9 leads to reduced zinc-binding.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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