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Rabbit Anti-SLC39A7 Recombinant Antibody (CBXS-0473) (CBMAB-S3423-CQ)

This product is a rabbit antibody that recognizes SLC39A7. The antibody CBXS-0473 can be used for immunoassay techniques such as: WB, IP.
See all SLC39A7 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
CBXS-0473
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Solute Carrier Family 39 Member 7
Introduction
The protein encoded by this gene transports zinc from the Golgi and endoplasmic reticulum to the cytoplasm. This transport may be important for activation of tyrosine kinases, some of which could be involved in cancer progression. Therefore, modulation of the encoded protein could be useful as a therapeutic agent against cancer. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
Human7922
Mouse14977
UniProt ID
HumanQ92504
MouseQ31125
Alternative Names
Solute Carrier Family 39 Member 7; Solute Carrier Family 39 (Zinc Transporter), Member 7; HLA Class II Region Expressed Gene KE4; Really Interesting New Gene 5 Protein; Histidine-Rich Membrane Protein Ke4; Zrt-, Irt-Like Protein 7; RING5; HKE4;
Function
Zinc transporter, that transports Zn2+ from the endoplasmic reticulum/Golgi apparatus to the cytosol. Transport is stimulated by growth factors, such as EGF, and Ca2+, as well as by exogenous Zn2+. Has an essential role in B cell development and is required for proper B cell receptor signaling (PubMed:30718914).
Biological Process
Biological Process B cell differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular zinc ion homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process zinc ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Endoplasmic reticulum membrane
Golgi apparatus, cis-Golgi network membrane
Involvement in disease
Agammaglobulinemia 9, autosomal recessive (AGM9):
A form of agammaglobulinemia, a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.
PTM
Rapidly phosphorylated by CK2 following Zn2+ treatment. This phosphorylation is required for efficient cytosolic Zn2+ release.
Methylation at some His residue by METTL9 leads to reduced zinc-binding.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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