SLC39A7

The protein encoded by this gene transports zinc from the Golgi and endoplasmic reticulum to the cytoplasm. This transport may be important for activation of tyrosine kinases, some of which could be involved in cancer progression. Therefore, modulation of the encoded protein could be useful as a therapeutic agent against cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Full Name

Solute Carrier Family 39 Member 7

Function

Zinc transporter, that transports Zn2+ from the endoplasmic reticulum/Golgi apparatus to the cytosol. Transport is stimulated by growth factors, such as EGF, and Ca2+, as well as by exogenous Zn2+. Has an essential role in B cell development and is required for proper B cell receptor signaling (PubMed:30718914).

Biological Process

Biological Process B cell differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular zinc ion homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process zinc ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Endoplasmic reticulum membrane
Golgi apparatus, cis-Golgi network membrane

Involvement in disease

Agammaglobulinemia 9, autosomal recessive (AGM9):
A form of agammaglobulinemia, a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.

PTM

Rapidly phosphorylated by CK2 following Zn2+ treatment. This phosphorylation is required for efficient cytosolic Zn2+ release.
Methylation at some His residue by METTL9 leads to reduced zinc-binding.