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Mouse Anti-SLC41A1 Recombinant Antibody (CBXS-2087) (CBMAB-S4853-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-2087
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Solute Carrier Family 41 Member 1
Entrez Gene ID
254428
UniProt ID
Q8IVJ1
Alternative Names
Solute Carrier Family 41 Member 1; Solute Carrier Family 41 (Magnesium Transporter), Member 1; MgtE;
Function
Na+/Mg2+ ion exchanger that acts as a predominant Mg2+ efflux system at the plasma membrane (PubMed:22031603, PubMed:23661805, PubMed:18367447, PubMed:23976986).
Transporter activity is driven by the inwardly directed electrochemical gradient for Na+ ions, thus directly depends on the extracellular Na+ ion concentration set by Na+/K+ pump (PubMed:22031603, PubMed:23661805).
Generates circadian cellular Mg2+ fluxes that feed back to regulate clock-controlled gene expression and metabolism and facilitate higher energetic demands during the day (PubMed:27074515).
Has a role in regulating the activity of ATP-dependent enzymes, including those operating in Krebs cycle and the electron transport chain (By similarity).
Biological Process
Biological Process cellular magnesium ion homeostasisManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Biological Process cellular response to magnesium ionManual Assertion Based On ExperimentIGI:ParkinsonsUK-UCL
Biological Process magnesium ion transmembrane transportManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Biological Process magnesium ion transportManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Biological Process metal ion transportISS:ParkinsonsUK-UCL
Cellular Location
Cell membrane
Basolateral cell membrane
Involvement in disease
Nephronophthisis-like nephropathy 2 (NPHPL2):
A disorder with features of nephronophthisis, a cystic kidney disease leading to end-stage renal failure. Nephronophthisis is histologically characterized by modifications of the tubules with thickening of the basement membrane, interstitial fibrosis and, in the advanced stages, medullary cysts. Typical clinical manifestation are chronic renal failure, anemia, polyuria, polydipsia, isosthenuria, and growth retardation. Associations with extrarenal symptoms are frequent. NPHPL2 is an autosomal recessive form characterized by onset of progressive renal insufficiency in the first decades of life.
PTM
Phosphorylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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