Mouse Anti-SLC41A1 Recombinant Antibody (CBXS-2087) (CBMAB-S4853-CQ)

Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Transporter activity is driven by the inwardly directed electrochemical gradient for Na+ ions, thus directly depends on the extracellular Na+ ion concentration set by Na+/K+ pump (PubMed:22031603, PubMed:23661805).
Generates circadian cellular Mg2+ fluxes that feed back to regulate clock-controlled gene expression and metabolism and facilitate higher energetic demands during the day (PubMed:27074515).
Has a role in regulating the activity of ATP-dependent enzymes, including those operating in Krebs cycle and the electron transport chain (By similarity).
Biological Process cellular response to magnesium ionManual Assertion Based On ExperimentIGI:ParkinsonsUK-UCL
Biological Process magnesium ion transmembrane transportManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Biological Process magnesium ion transportManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Biological Process metal ion transportISS:ParkinsonsUK-UCL
Basolateral cell membrane
A disorder with features of nephronophthisis, a cystic kidney disease leading to end-stage renal failure. Nephronophthisis is histologically characterized by modifications of the tubules with thickening of the basement membrane, interstitial fibrosis and, in the advanced stages, medullary cysts. Typical clinical manifestation are chronic renal failure, anemia, polyuria, polydipsia, isosthenuria, and growth retardation. Associations with extrarenal symptoms are frequent. NPHPL2 is an autosomal recessive form characterized by onset of progressive renal insufficiency in the first decades of life.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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