SLC41A1

Full Name

Solute Carrier Family 41 Member 1

Function

Na+/Mg2+ ion exchanger that acts as a predominant Mg2+ efflux system at the plasma membrane (PubMed:22031603, PubMed:23661805, PubMed:18367447, PubMed:23976986).
Transporter activity is driven by the inwardly directed electrochemical gradient for Na+ ions, thus directly depends on the extracellular Na+ ion concentration set by Na+/K+ pump (PubMed:22031603, PubMed:23661805).
Generates circadian cellular Mg2+ fluxes that feed back to regulate clock-controlled gene expression and metabolism and facilitate higher energetic demands during the day (PubMed:27074515).
Has a role in regulating the activity of ATP-dependent enzymes, including those operating in Krebs cycle and the electron transport chain (By similarity).

Biological Process

Biological Process cellular magnesium ion homeostasisManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Biological Process cellular response to magnesium ionManual Assertion Based On ExperimentIGI:ParkinsonsUK-UCL
Biological Process magnesium ion transmembrane transportManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Biological Process magnesium ion transportManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Biological Process metal ion transportISS:ParkinsonsUK-UCL

Cellular Location

Cell membrane
Basolateral cell membrane

Involvement in disease

Nephronophthisis-like nephropathy 2 (NPHPL2):
A disorder with features of nephronophthisis, a cystic kidney disease leading to end-stage renal failure. Nephronophthisis is histologically characterized by modifications of the tubules with thickening of the basement membrane, interstitial fibrosis and, in the advanced stages, medullary cysts. Typical clinical manifestation are chronic renal failure, anemia, polyuria, polydipsia, isosthenuria, and growth retardation. Associations with extrarenal symptoms are frequent. NPHPL2 is an autosomal recessive form characterized by onset of progressive renal insufficiency in the first decades of life.

PTM

Phosphorylated.