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Mouse Anti-SLC5A12 Recombinant Antibody (CBXS-2293) (CBMAB-S5055-CQ)

This product is a mouse antibody that recognizes SLC5A12. The antibody CBXS-2293 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all SLC5A12 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-2293
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Solute Carrier Family 5 Member 12
Introduction
Normal blood lactate is maintained at about 1.5 mM, and little filtered lactate is excreted in urine. Reabsorption of lactate is mediated by the low-affinity Na(+)-coupled lactate transporter SLC5A12 in the initial part of the proximal tubule and by the high-affinity Na(+)-coupled lactate transporter SLC5A8 (MIM 608044) in the distal proximal tubule (Gopal et al., 2007 [PubMed 17692818]).
Entrez Gene ID
159963
UniProt ID
Q1EHB4
Alternative Names
Solute Carrier Family 5 Member 12; Solute Carrier Family 5 (Sodium/Monocarboxylate Cotransporter), Member 12; Solute Carrier Family 5 (Sodium/Glucose Cotransporter), Member 12; Electroneutral Sodium Monocarboxylate Cotransporter; Low-Affinity Sodium-Lactate Cotransporter; SMCT2; Sodium-Coupled Monocarboxylate Transporter 2; Sodium-Iodide Related Cotransporter;
Function
Acts as an electroneutral and low-affinity sodium (Na+)-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D-hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina (By similarity).
Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na+ for each lactate (By similarity).
Biological Process
Biological Process ion transportTAS:Reactome
Biological Process sodium ion transportManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Apical cell membrane
Detected at the brush border membrane of the kidney. Colocalizes with viementin in Mueller cells (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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