SLC5A12

Normal blood lactate is maintained at about 1.5 mM, and little filtered lactate is excreted in urine. Reabsorption of lactate is mediated by the low-affinity Na(+)-coupled lactate transporter SLC5A12 in the initial part of the proximal tubule and by the high-affinity Na(+)-coupled lactate transporter SLC5A8 (MIM 608044) in the distal proximal tubule (Gopal et al., 2007 [PubMed 17692818]).

Full Name

Solute Carrier Family 5 Member 12

Function

Acts as an electroneutral and low-affinity sodium (Na+)-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D-hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina (By similarity).
Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na+ for each lactate (By similarity).

Biological Process

Biological Process ion transportTAS:Reactome
Biological Process sodium ion transportManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Apical cell membrane
Detected at the brush border membrane of the kidney. Colocalizes with viementin in Mueller cells (By similarity).