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Mouse Anti-SLC9A6 Recombinant Antibody (CBXS-2878) (CBMAB-S5628-CQ)

This product is a mouse antibody that recognizes SLC9A6. The antibody CBXS-2878 can be used for immunoassay techniques such as: ELISA, WB.
See all SLC9A6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-2878
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa602-669 from SLC9A6 (NP_006350) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
solute carrier family 9 (sodium/hydrogen exchanger), member 6
Introduction
This gene encodes a sodium-hydrogen exchanger that is amember of the solute carrier family 9. The encoded protein localizes to early and recycling endosomes and may be involved in regulating endosomal pH and volume. Defects in this gene are associated with X-linked syndromic cognitive disability, Christianson type. Alternate splicing results in multiple transcript variants.
Entrez Gene ID
10479
UniProt ID
Q92581
Alternative Names
Solute Carrier Family 9 Member A6; Solute Carrier Family 9, Subfamily A (NHE6, Cation Proton Antiporter 6), Member 6; Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Member 6; Na(+)/H(+) Exchanger 6; NHE6; Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Isoform 6;
Function
Electroneutral exchange of protons for Na+ and K+ across the early and recycling endosome membranes. Contributes to calcium homeostasis.
Biological Process
Biological Process axon extensionManual Assertion Based On ExperimentIDA:MGI
Biological Process dendrite extensionManual Assertion Based On ExperimentIDA:MGI
Biological Process ion transportTAS:Reactome
Biological Process neuron projection morphogenesisManual Assertion Based On ExperimentIDA:MGI
Biological Process potassium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of intracellular pHManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process sodium ion import across plasma membraneManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Endosome membrane
Is present in the recycling compartments including early and recycling endosomes, and only appears transiently on the plasma membrane.
Isoform 2
Recycling endosome membrane
Involvement in disease
Intellectual developmental disorder, X-linked, syndromic, Christianson type (MRXSCH):
A syndrome characterized by profound intellectual disability, epilepsy, ataxia, and microcephaly. It shows phenotypic overlap with Angelman syndrome.
PTM
Ubiquitinated (in vitro).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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