Mouse Anti-SLC9B2 Recombinant Antibody (CBWJN-1047) (CBMAB-N0613-WJ)

Name: Mouse Anti-SLC9B2 Recombinant Antibody (CBWJN-1047)
SKU: CBMAB-N0613-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBWJN-1047

Application

FC, CyTOF

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, Trehalose

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Solute Carrier Family 9 Member B2

Introduction

Sodium hydrogen antiporters, such as NHEDC2, convert the proton motive force established by the respiratory chain or the F1F0 mitochondrial ATPase into sodium gradients that drive other energy-requiring processes, transduce environmental signals into cell responses, or function in drug efflux (Xiang et al., 2007 [PubMed 18000046]).[supplied by OMIM, Mar 2008]

Entrez Gene ID

133308

UniProt ID

Q86UD5

Alternative Names

Solute Carrier Family 9 Member B2; Solute Carrier Family 9, Subfamily B (NHA2, Cation Proton Antiporter 2), Member 2; Solute Carrier Family 9, Subfamily B (Cation Proton Antiporter 2), Member 2; Sodium/Hydrogen Exchanger-Like Domain-Containing Protein 2; Na(+)/H(+) Exchanger-Like Domain-Containing Protein 2; Solute Carrier Family 9 Subfamily B Member 2; Na+/H+ Exchanger Domain Containing 2; NHE Domain-Containing Protein 2; Na(+)/H(+) Exchanger NHA2;

Function

Na+/H+ antiporter that extrudes Na+ or Li+ in exchange for external protons across the membrane (PubMed:18000046, PubMed:28154142, PubMed:22948142, PubMed:18508966).
Contributes to the regulation of intracellular pH, sodium homeostasis, and cell volume. Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta-cells (By similarity).
Involved in sperm motility and fertility (By similarity).
It is controversial whether SLC9B2 plays a role in osteoclast differentiation or not (By similarity).

Biological Process

Biological Process clathrin-dependent endocytosisIEA:Ensembl
Biological Process flagellated sperm motilityISS:UniProtKB
Biological Process ion transmembrane transportTAS:Reactome
Biological Process positive regulation of osteoclast developmentIEA:Ensembl
Biological Process regulation of insulin secretion involved in cellular response to glucose stimulusIEA:Ensembl
Biological Process sodium ion transportManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cell membrane
Mitochondrion membrane
Endosome membrane
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Cell projection, cilium, flagellum membrane
Basolateral cell membrane
Apical cell membrane
Strong colocalization with LAMP1 and TCIRG1 in osteoclasts. In beta-cells colocalizes with RAB4A and SYP. Localizes to the basolateral membrane of polarized osteoclasts.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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