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Mouse Anti-SLC9B2 Recombinant Antibody (CBWJN-1047) (CBMAB-N0613-WJ)

This product is a Mouse antibody that recognizes SLC9B2. The antibody CBWJN-1047 can be used for immunoassay techniques such as: FC, CyTOF.
See all SLC9B2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJN-1047
Antibody Isotype
IgG2b
Application
FC, CyTOF

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Solute Carrier Family 9 Member B2
Introduction
Sodium hydrogen antiporters, such as NHEDC2, convert the proton motive force established by the respiratory chain or the F1F0 mitochondrial ATPase into sodium gradients that drive other energy-requiring processes, transduce environmental signals into cell responses, or function in drug efflux (Xiang et al., 2007 [PubMed 18000046]).[supplied by OMIM, Mar 2008]
Entrez Gene ID
133308
UniProt ID
Q86UD5
Alternative Names
Solute Carrier Family 9 Member B2; Solute Carrier Family 9, Subfamily B (NHA2, Cation Proton Antiporter 2), Member 2; Solute Carrier Family 9, Subfamily B (Cation Proton Antiporter 2), Member 2; Sodium/Hydrogen Exchanger-Like Domain-Containing Protein 2; Na(+)/H(+) Exchanger-Like Domain-Containing Protein 2; Solute Carrier Family 9 Subfamily B Member 2; Na+/H+ Exchanger Domain Containing 2; NHE Domain-Containing Protein 2; Na(+)/H(+) Exchanger NHA2;
Function
Na+/H+ antiporter that extrudes Na+ or Li+ in exchange for external protons across the membrane (PubMed:18000046, PubMed:28154142, PubMed:22948142, PubMed:18508966).
Contributes to the regulation of intracellular pH, sodium homeostasis, and cell volume. Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta-cells (By similarity).
Involved in sperm motility and fertility (By similarity).
It is controversial whether SLC9B2 plays a role in osteoclast differentiation or not (By similarity).
Biological Process
Biological Process clathrin-dependent endocytosisIEA:Ensembl
Biological Process flagellated sperm motilityISS:UniProtKB
Biological Process ion transmembrane transportTAS:Reactome
Biological Process positive regulation of osteoclast developmentIEA:Ensembl
Biological Process regulation of insulin secretion involved in cellular response to glucose stimulusIEA:Ensembl
Biological Process sodium ion transportManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cell membrane
Mitochondrion membrane
Endosome membrane
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Cell projection, cilium, flagellum membrane
Basolateral cell membrane
Apical cell membrane
Strong colocalization with LAMP1 and TCIRG1 in osteoclasts. In beta-cells colocalizes with RAB4A and SYP. Localizes to the basolateral membrane of polarized osteoclasts.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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