SLC9B2

Sodium hydrogen antiporters, such as NHEDC2, convert the proton motive force established by the respiratory chain or the F1F0 mitochondrial ATPase into sodium gradients that drive other energy-requiring processes, transduce environmental signals into cell responses, or function in drug efflux (Xiang et al., 2007 [PubMed 18000046]).

Full Name

Solute Carrier Family 9 Member B2

Function

Na+/H+ antiporter that extrudes Na+ or Li+ in exchange for external protons across the membrane (PubMed:18000046, PubMed:28154142, PubMed:22948142, PubMed:18508966).
Contributes to the regulation of intracellular pH, sodium homeostasis, and cell volume. Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta-cells (By similarity).
Involved in sperm motility and fertility (By similarity).
It is controversial whether SLC9B2 plays a role in osteoclast differentiation or not (By similarity).

Biological Process

Biological Process clathrin-dependent endocytosisIEA:Ensembl
Biological Process flagellated sperm motilityISS:UniProtKB
Biological Process ion transmembrane transportTAS:Reactome
Biological Process positive regulation of osteoclast developmentIEA:Ensembl
Biological Process regulation of insulin secretion involved in cellular response to glucose stimulusIEA:Ensembl
Biological Process sodium ion transportManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cell membrane
Mitochondrion membrane
Endosome membrane
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
Cell projection, cilium, flagellum membrane
Basolateral cell membrane
Apical cell membrane
Strong colocalization with LAMP1 and TCIRG1 in osteoclasts. In beta-cells colocalizes with RAB4A and SYP. Localizes to the basolateral membrane of polarized osteoclasts.