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Mouse Anti-SLIRP Recombinant Antibody (CBXS-4036) (CBMAB-S1297-CQ)

This product is a mouse antibody that recognizes SLIRP. The antibody CBXS-4036 can be used for immunoassay techniques such as: WB, ICC, FC, ELISA.
See all SLIRP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4036
Antibody Isotype
IgG1
Application
WB, ICC, FC, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SRA stem-loop interacting RNA binding protein
Introduction
Steroid receptor RNA activator (SRA, or SRA1; MIM 603819) is a complex RNA molecule containing multiple stable stem-loop structures that functions in coactivation of nuclear receptors. SLIRP interacts with stem-loop structure-7 of SRA (STR7) and modulates nuclear receptor transactivation (Hatchell et al., 2006 [PubMed 16762838]).
Entrez Gene ID
81892
UniProt ID
Q9GZT3
Alternative Names
SRA Stem-Loop Interacting RNA Binding Protein; C14orf156; SRA Stem-Loop-Interacting RNA-Binding Protein, Mitochondrial; Chromosome 14 Open Reading Frame 156; PD04872; DC50;
Function
RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation.
Biological Process
Biological Process flagellated sperm motilityIEA:Ensembl
Biological Process mitochondrion morphogenesisIEA:Ensembl
Biological Process negative regulation of mitochondrial RNA catabolic processIEA:Ensembl
Biological Process single fertilizationIEA:Ensembl
Biological Process spermatid developmentIEA:Ensembl
Cellular Location
Mitochondrion
Nucleus
Predominantly mitochondrial. Some fraction is nuclear. In the nucleus, it is recruited to nuclear receptor target promoters.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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