Mouse Anti-SLIRP Recombinant Antibody (CBXS-4036) (CBMAB-S1297-CQ)

Name: Mouse Anti-SLIRP Recombinant Antibody (CBXS-4036)
SKU: CBMAB-S1297-CQ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBXS-4036

Application

WB, ICC, FC, ELISA

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

SRA stem-loop interacting RNA binding protein

Introduction

Steroid receptor RNA activator (SRA, or SRA1; MIM 603819) is a complex RNA molecule containing multiple stable stem-loop structures that functions in coactivation of nuclear receptors. SLIRP interacts with stem-loop structure-7 of SRA (STR7) and modulates nuclear receptor transactivation (Hatchell et al., 2006 [PubMed 16762838]).

Entrez Gene ID

81892

UniProt ID

Q9GZT3

Alternative Names

SRA Stem-Loop Interacting RNA Binding Protein; C14orf156; SRA Stem-Loop-Interacting RNA-Binding Protein, Mitochondrial; Chromosome 14 Open Reading Frame 156; PD04872; DC50;

Function

RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation.

Biological Process

Biological Process flagellated sperm motilityIEA:Ensembl
Biological Process mitochondrion morphogenesisIEA:Ensembl
Biological Process negative regulation of mitochondrial RNA catabolic processIEA:Ensembl
Biological Process single fertilizationIEA:Ensembl
Biological Process spermatid developmentIEA:Ensembl

Cellular Location

Mitochondrion
Nucleus
Predominantly mitochondrial. Some fraction is nuclear. In the nucleus, it is recruited to nuclear receptor target promoters.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-SLIRP Recombinant Antibody (CBXS-2052) (CAT#: CBMAB-S4819-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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