SLIRP

Steroid receptor RNA activator (SRA, or SRA1; MIM 603819) is a complex RNA molecule containing multiple stable stem-loop structures that functions in coactivation of nuclear receptors. SLIRP interacts with stem-loop structure-7 of SRA (STR7) and modulates nuclear receptor transactivation (Hatchell et al., 2006 [PubMed 16762838]).

Full Name

SRA stem-loop interacting RNA binding protein

Function

RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation.

Biological Process

Biological Process flagellated sperm motilityIEA:Ensembl
Biological Process mitochondrion morphogenesisIEA:Ensembl
Biological Process negative regulation of mitochondrial RNA catabolic processIEA:Ensembl
Biological Process single fertilizationIEA:Ensembl
Biological Process spermatid developmentIEA:Ensembl

Cellular Location

Mitochondrion
Nucleus
Predominantly mitochondrial. Some fraction is nuclear. In the nucleus, it is recruited to nuclear receptor target promoters.