SLIRP

Steroid receptor RNA activator (SRA, or SRA1; MIM 603819) is a complex RNA molecule containing multiple stable stem-loop structures that functions in coactivation of nuclear receptors. SLIRP interacts with stem-loop structure-7 of SRA (STR7) and modulates nuclear receptor transactivation (Hatchell et al., 2006 [PubMed 16762838]).

Full Name

SRA stem-loop interacting RNA binding protein

Function

RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation.

Biological Process

Biological Process flagellated sperm motilityIEA:Ensembl
Biological Process mitochondrion morphogenesisIEA:Ensembl
Biological Process negative regulation of mitochondrial RNA catabolic processIEA:Ensembl
Biological Process single fertilizationIEA:Ensembl
Biological Process spermatid developmentIEA:Ensembl

Cellular Location

Mitochondrion
Nucleus
Predominantly mitochondrial. Some fraction is nuclear. In the nucleus, it is recruited to nuclear receptor target promoters.

Anti-SLIRP antibodies

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-SLIRP Recombinant Antibody (CBXS-4036) (CBMAB-S1297-CQ)

Datasheet

SDS

Target: SLIRP

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-4036

Application*: WB, IC, F, E

Mouse Anti-SLIRP Recombinant Antibody (CBXS-2052) (CBMAB-S4819-CQ)

Datasheet

SDS

Target: SLIRP

Host: Mouse

Specificity: Mouse

Clone: CBXS-2052

Application*: WB, IP, IF, E

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)