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Mouse Anti-SLMAP Recombinant Antibody (CBXS-0508) (CBMAB-S3457-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-0508
Antibody Isotype
IgG2a, κ
Application
S-ELISA, ELISA, WB, IHC-P

Basic Information

Immunogen
SLMAP (NP_009090, 677 a.a.-784 a.a) partial recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
sarcolemma associated protein
Introduction
This gene encodes a component of a conserved striatin-interacting phosphatase and kinase complex. Striatin family complexes participate in a variety of cellular processes including signaling, cell cycle control, cell migration, Golgi assembly, and apoptosis. The protein encoded by this gene is a coiled-coil, tail-anchored membrane protein with a single C-terminal transmembrane domain that is posttranslationally inserted into membranes. Mutations in this gene are associated with Brugada syndrome, a cardiac channelopathy. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
7871
UniProt ID
Q14BN4
Alternative Names
Sarcolemma Associated Protein; Sarcolemmal-Associated Protein; SLAP; Sarcolemmal Membrane-Associated Protein; KIAA1601;
Function
May play a role during myoblast fusion.
Biological Process
Biological Process muscle contractionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process protein localization to plasma membraneManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of membrane depolarization during cardiac muscle cell action potentialManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of sodium ion transmembrane transportManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of voltage-gated sodium channel activityManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular Location
Cell membrane, sarcolemma
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Membrane-associated. Distributed in the transverse tubules and near the junctional sarcoplasmic reticulum. Detected along the Z- and M-lines in cardiomyocytes. Centrosome. Localizes to the centrosomes in a microtubule- dependent manner (By similarity).
Topology
Cytoplasmic: 1-802
Helical: 803-823
Extracellular: 824-828
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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