SLMAP

This gene encodes a component of a conserved striatin-interacting phosphatase and kinase complex. Striatin family complexes participate in a variety of cellular processes including signaling, cell cycle control, cell migration, Golgi assembly, and apoptosis. The protein encoded by this gene is a coiled-coil, tail-anchored membrane protein with a single C-terminal transmembrane domain that is posttranslationally inserted into membranes. Mutations in this gene are associated with Brugada syndrome, a cardiac channelopathy. Alternative splicing results in multiple transcript variants.

sarcolemma associated protein

May play a role during myoblast fusion.

Biological Process muscle contractionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process protein localization to plasma membraneManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of membrane depolarization during cardiac muscle cell action potentialManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of sodium ion transmembrane transportManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of voltage-gated sodium channel activityManual Assertion Based On ExperimentIMP:BHF-UCL

Cell membrane, sarcolemma
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Membrane-associated. Distributed in the transverse tubules and near the junctional sarcoplasmic reticulum. Detected along the Z- and M-lines in cardiomyocytes. Centrosome. Localizes to the centrosomes in a microtubule- dependent manner (By similarity).

Cytoplasmic: 1-802
Helical: 803-823
Extracellular: 824-828