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Rabbit Anti-SMG5 Recombinant Antibody (CBXS-1492) (CBMAB-S4345-CQ)

This product is a rabbit antibody that recognizes SMG5. The antibody CBXS-1492 can be used for immunoassay techniques such as: WB, IHC-P, IF.
See all SMG5 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBXS-1492
Antibody Isotype
IgG
Application
WB, IHC-P, IF

Basic Information

Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SMG5, Nonsense Mediated MRNA Decay Factor
Introduction
SMG5 is involved in nonsense-mediated mRNA decay (Ohnishi et al., 2003 [PubMed 14636577]).
Entrez Gene ID
23381
UniProt ID
Q9UPR3
Alternative Names
SMG5, Nonsense Mediated MRNA Decay Factor; EST1-Like Protein B; LPTS-RP1; EST1B; Smg-5 Homolog, Nonsense Mediated MRNA Decay Factor (C. Elegans); EST1 Telomerase Component Homolog B (S. Cerevisiae); Smg-5 Homolog, Nonsense Mediated MRNA Decay Factor; EST1 Telomerase Component Homolog B; Ever Shorter Telomeres 1B; LPTS Interacting Protein;
Function
Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity.
Biological Process
Biological Process mRNA export from nucleusManual Assertion Based On ExperimentTAS:HGNC-UCL
Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of dephosphorylationManual Assertion Based On ExperimentIMP:HGNC-UCL
Biological Process regulation of telomere maintenanceManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of telomere maintenance via telomeraseManual Assertion Based On ExperimentTAS:BHF-UCL
Cellular Location
Cytoplasm
Nucleus
Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm. Detected in cytoplasmic mRNA decay bodies.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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