Rabbit Anti-SMG5 Recombinant Antibody (CBXS-1492) (CBMAB-S4345-CQ)

Name: Rabbit Anti-SMG5 Recombinant Antibody (CBXS-1492)
SKU: CBMAB-S4345-CQ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Rabbit

Clone

CBXS-1492

Application

WB, IHC-P, IF

Specificity

Human

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

SMG5, Nonsense Mediated MRNA Decay Factor

Introduction

SMG5 is involved in nonsense-mediated mRNA decay (Ohnishi et al., 2003 [PubMed 14636577]).

Entrez Gene ID

23381

UniProt ID

Q9UPR3

Alternative Names

SMG5, Nonsense Mediated MRNA Decay Factor; EST1-Like Protein B; LPTS-RP1; EST1B; Smg-5 Homolog, Nonsense Mediated MRNA Decay Factor (C. Elegans); EST1 Telomerase Component Homolog B (S. Cerevisiae); Smg-5 Homolog, Nonsense Mediated MRNA Decay Factor; EST1 Telomerase Component Homolog B; Ever Shorter Telomeres 1B; LPTS Interacting Protein;

Function

Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity.

Biological Process

Biological Process mRNA export from nucleusManual Assertion Based On ExperimentTAS:HGNC-UCL
Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of dephosphorylationManual Assertion Based On ExperimentIMP:HGNC-UCL
Biological Process regulation of telomere maintenanceManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of telomere maintenance via telomeraseManual Assertion Based On ExperimentTAS:BHF-UCL

Cellular Location

Cytoplasm
Nucleus
Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm. Detected in cytoplasmic mRNA decay bodies.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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