SMG5

SMG5 is involved in nonsense-mediated mRNA decay (Ohnishi et al., 2003 [PubMed 14636577]).

SMG5, Nonsense Mediated MRNA Decay Factor

Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity.

Biological Process mRNA export from nucleusManual Assertion Based On ExperimentTAS:HGNC-UCL
Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of dephosphorylationManual Assertion Based On ExperimentIMP:HGNC-UCL
Biological Process regulation of telomere maintenanceManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of telomere maintenance via telomeraseManual Assertion Based On ExperimentTAS:BHF-UCL

Cytoplasm
Nucleus
Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm. Detected in cytoplasmic mRNA decay bodies.