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Rabbit Anti-SNAP29 Recombinant Antibody (CBXS-1627) (CBMAB-S4476-CQ)

This product is a rabbit antibody that recognizes SNAP29. The antibody CBXS-1627 can be used for immunoassay techniques such as: WB, IP, FC, IF.
See all SNAP29 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBXS-1627
Antibody Isotype
IgG
Application
WB, IP, FC, IF

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
synaptosomal-associated protein, 29kDa
Introduction
This gene, a member of the SNAP25 gene family, encodes a protein involved in multiple membrane trafficking steps. Two other members of this gene family, SNAP23 and SNAP25, encode proteins that bind a syntaxin protein and mediate synaptic vesicle membrane docking and fusion to the plasma membrane. The protein encoded by this gene binds tightly to multiple syntaxins and is localized to intracellular membrane structures rather than to the plasma membrane. While the protein is mostly membrane-bound, a significant fraction of it is found free in the cytoplasm. Use of multiple polyadenylation sites has been noted for this gene.
Entrez Gene ID
Human9342
Mouse67474
Rat116500
UniProt ID
HumanO95721
MouseQ9ERB0
RatQ9Z2P6
Alternative Names
Synaptosome Associated Protein 29; Soluble 29 KDa NSF Attachment Protein; Vesicle-Membrane Fusion Protein SNAP-29; Synaptosomal-Associated Protein, 29kDa; SNAP-29; Synaptosomal-Associated Protein, 29kD; Synaptosome Associated Protein 29kDa; Synaptosomal-Associated Protein 29; CEDNIK;
Function
SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Also plays a role in ciliogenesis by regulating membrane fusions.
Biological Process
Biological Process autophagosome maturationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process autophagosome membrane dockingManual Assertion Based On ExperimentIDA:GO_Central
Biological Process cilium assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process exocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process membrane fusionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process protein transportIEA:UniProtKB-KW
Biological Process synaptic vesicle fusion to presynaptic active zone membraneManual Assertion Based On ExperimentIBA:GO_Central
Biological Process synaptic vesicle primingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process vesicle fusionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process vesicle targetingManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm
Golgi apparatus membrane
Cytoplasmic vesicle, autophagosome membrane
Cell projection, cilium membrane
Appears to be mostly membrane-bound, probably via interaction with syntaxins, but a significant portion is cytoplasmic. Localizes to the ciliary pocket from where the cilium protrudes.
Involvement in disease
Cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome (CEDNIK):
A neurocutaneous syndrome characterized by cerebral dysgenesis, neuropathy, ichthyosis and palmoplantar keratoderma.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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