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Rat Anti-SNRPC Recombinant Antibody (CBXS-5099) (CBMAB-S2317-CQ)

This product is a rat antibody that recognizes SNRPC. The antibody CBXS-5099 can be used for immunoassay techniques such as: WB, IP, ELISA, IF.
See all SNRPC antibodies

Summary

Host Animal
Rat
Specificity
Mouse, Human, Monkey
Clone
CBXS-5099
Antibody Isotype
IgG2a
Application
WB, IP, ELISA, IF

Basic Information

Specificity
Mouse, Human, Monkey
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Small Nuclear Ribonucleoprotein Polypeptide C
Introduction
This gene encodes one of the specific protein components of the U1 small nuclear ribonucleoprotein (snRNP) particle required for the formation of the spliceosome. The encoded protein participates in the processing of nuclear precursor messenger RNA splicing. snRNP particles are attacked by autoantibodies frequently produced by patients with connective tissue diseases. The genome contains several pseudogenes of this functional gene. Alternative splicing results in a non-coding transcript variant.
Entrez Gene ID
Human6631
Mouse20630
Monkey718654
UniProt ID
HumanP09234
MouseQ62241
MonkeyF6TFD9
Alternative Names
Small Nuclear Ribonucleoprotein Polypeptide C; U1 SnRNP C; U1C; U1 Small Nuclear Ribonucleoprotein C; U1 Small Nuclear RNP Specific C; U1 SnRNP Protein C; Yhc1; U1-C;
Function
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
Biological Process
Biological Process mRNA 5'-splice site recognitionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process spliceosomal snRNP assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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