SNRPC

This gene encodes one of the specific protein components of the U1 small nuclear ribonucleoprotein (snRNP) particle required for the formation of the spliceosome. The encoded protein participates in the processing of nuclear precursor messenger RNA splicing. snRNP particles are attacked by autoantibodies frequently produced by patients with connective tissue diseases. The genome contains several pseudogenes of this functional gene. Alternative splicing results in a non-coding transcript variant.
Full Name
Small Nuclear Ribonucleoprotein Polypeptide C
Function
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
Biological Process
Biological Process mRNA 5'-splice site recognitionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process spliceosomal snRNP assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
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Anti-SNRPC antibodies

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Mouse Anti-SNRPC Recombinant Antibody (CBXS-2163) (CBMAB-S4926-CQ)

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Target: SNRPC
Host: Mouse
Specificity: Human
Clone: CBXS-2163
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-SNRPC Recombinant Antibody (CBXS-2090) (CBMAB-S4855-CQ)

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Target: SNRPC
Host: Mouse
Specificity: Human
Clone: CBXS-2090
Application*: WB, IP, IF, P, E
Datasheet SDS

Rabbit Anti-SNRPC Recombinant Antibody (CBXS-1411) (CBMAB-S4269-CQ)

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Target: SNRPC
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBXS-1411
Application*: WB, IP, P, IF
Datasheet SDS

Rat Anti-SNRPC Recombinant Antibody (CBXS-5099) (CBMAB-S2317-CQ)

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Target: SNRPC
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse, Human, Monkey
Clone: CBXS-5099
Application*: WB, IP, E, IF
Datasheet SDS

Rat Anti-SNRPC Recombinant Antibody (CBFYS-007) (CBMAB-S0007-FY)

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Target: SNRPC
Host: Rat
Specificity: Human, Monkey, Mouse
Clone: CBFYS-007
Application*: WB, E, IC, IP
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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