Mouse Anti-SNTA1 Recombinant Antibody (CBXS-4414) (CBMAB-S1656-CQ)

Name: Mouse Anti-SNTA1 Recombinant Antibody (CBXS-4414)
SKU: CBMAB-S1656-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-4414

Application

Immunogen

Recombinant full length human SNTA1 (NP_003089) produced in HEK293T cell

Specificity

Human, Monkey, Rat

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Syntrophin Alpha 1

Introduction

Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue.

Entrez Gene ID

Human	6640
Rat	362242
Monkey	709824

UniProt ID

Human	Q13424
Rat	B5DFL0
Monkey	I2CXI7

Alternative Names

Syntrophin Alpha 1; Pro-TGF-Alpha Cytoplasmic Domain-Interacting Protein 1; 59 KDa Dystrophin-Associated Protein A1 Acidic Component 1; Dystrophin-Associated Protein A1, 59kDa, Acidic Component; Syntrophin-1; TACIP1; SNT1;

Function

Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate (By similarity).

Biological Process

Biological Process muscle contractionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of peptidyl-cysteine S-nitrosylationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process neuromuscular junction developmentIEA:Ensembl
Biological Process regulation of heart rateManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of sodium ion transmembrane transportManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of vasoconstriction by circulating norepinephrineIEA:Ensembl
Biological Process regulation of ventricular cardiac muscle cell membrane repolarizationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process ventricular cardiac muscle cell action potentialManual Assertion Based On ExperimentIMP:BHF-UCL

Cellular Location

Cell membrane, sarcolemma
Cell junction
Cytoplasm, cytoskeleton
In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions.

Involvement in disease

Long QT syndrome 12 (LQT12):
A heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy.

PTM

Phosphorylated by CaM-kinase II. Phosphorylation may inhibit the interaction with DMD (By similarity).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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