SNTA1

Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue.
Full Name
Syntrophin Alpha 1
Function
Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate (By similarity).
Biological Process
Biological Process muscle contractionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of peptidyl-cysteine S-nitrosylationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process neuromuscular junction developmentIEA:Ensembl
Biological Process regulation of heart rateManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of sodium ion transmembrane transportManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of vasoconstriction by circulating norepinephrineIEA:Ensembl
Biological Process regulation of ventricular cardiac muscle cell membrane repolarizationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process ventricular cardiac muscle cell action potentialManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular Location
Cell membrane, sarcolemma
Cell junction
Cytoplasm, cytoskeleton
In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions.
Involvement in disease
Long QT syndrome 12 (LQT12):
A heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy.
PTM
Phosphorylated by CaM-kinase II. Phosphorylation may inhibit the interaction with DMD (By similarity).
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Anti-SNTA1 antibodies

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Mouse Anti-SNTA1 Recombinant Antibody (CBXS-2608) (CBMAB-S5363-CQ)

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Target: SNTA1
Host: Mouse
Specificity: Human
Clone: CBXS-2608
Application*: E, WB
Datasheet SDS

Rabbit Anti-SNTA1 Recombinant Antibody (CBXS-1390) (CBMAB-S4248-CQ)

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Target: SNTA1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Human
Clone: CBXS-1390
Application*: WB, P, F, IF
Datasheet SDS

Mouse Anti-SNTA1 (Cytoplasmic Domain) Recombinant Antibody (CBXS-0618) (CBMAB-S3560-CQ)

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Target: SNTA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-0618
Application*: IF, IP, WB
Datasheet SDS

Mouse Anti-SNTA1 Recombinant Antibody (CBXS-6105) (CBMAB-S2940-CQ)

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Target: SNTA1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXS-6105
Application*: E, WB
Datasheet SDS

Mouse Anti-SNTA1 Recombinant Antibody (CBXS-4518) (CBMAB-S1759-CQ)

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Target: SNTA1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4518
Application*: WB
Datasheet SDS

Mouse Anti-SNTA1 Recombinant Antibody (CBXS-4499) (CBMAB-S1741-CQ)

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Target: SNTA1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4499
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-SNTA1 Recombinant Antibody (CBXS-4414) (CBMAB-S1656-CQ)

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Target: SNTA1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Monkey, Rat
Clone: CBXS-4414
Application*: WB
Datasheet SDS

Mouse Anti-SNTA1 Recombinant Antibody (CBXS-4393) (CBMAB-S1636-CQ)

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Target: SNTA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4393
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-SNTA1 Recombinant Antibody (CBXS-4201) (CBMAB-S1454-CQ)

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Target: SNTA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Monkey, Rat
Clone: CBXS-4201
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-SNTA1 Recombinant Antibody (CBXS-4085) (CBMAB-S1342-CQ)

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Target: SNTA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4085
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-SNTA1 Recombinant Antibody (CBXS-3937) (CBMAB-S1202-CQ)

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Target: SNTA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3937
Application*: F, WB
Datasheet SDS

Mouse Anti-SNTA1 Recombinant Antibody (CBXS-3588) (CBMAB-S0205-CQ)

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Target: SNTA1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXS-3588
Application*: WB, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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