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Rabbit Anti-SNX17 Recombinant Antibody (E8F8Y) (CBMAB-CP2531-LY)

The product is antibody recognizes SNX17. The antibody E8F8Y immunoassay techniques such as: WB.
See all SNX17 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
E8F8Y
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asn54 of human SNX17 protein.
Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Sorting Nexin 17
Introduction
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012]
Entrez Gene ID
Human9784
Mouse266781
Rat298836
Monkey701614
UniProt ID
HumanQ15036
MouseQ8BVL3
RatQ6AYS6
MonkeyF7H9A0
Alternative Names
Sorting Nexin 17; KIAA0064;
Function
Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (PubMed:15121882, PubMed:15769472).
Binds to NPxY sequences in the cytoplasmic tails of target cargos (PubMed:21512128).
Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (PubMed:28892079, PubMed:22492727).
Also required for maintenance of normal cell surface levels of APP and LRP1 (PubMed:16712798, PubMed:19005208).
Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:16712798).
Biological Process
Biological Process aorta developmentIEA:Ensembl
Biological Process cardiac septum developmentIEA:Ensembl
Biological Process cholesterol catabolic process1 PublicationIC:UniProtKB
Biological Process coronary vasculature developmentIEA:Ensembl
Biological Process endocytic recyclingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endosomal transport1 PublicationNAS:UniProtKB
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process kidney developmentIEA:Ensembl
Biological Process receptor-mediated endocytosisIEA:Ensembl
Biological Process regulation of endocytosis1 PublicationNAS:UniProtKB
Biological Process signal transductionIEA:InterPro
Cellular Location
Cytoplasm
Early endosome
Cytoplasmic vesicle membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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