Rabbit Anti-SNX17 Recombinant Antibody (E8F8Y) (CBMAB-CP2531-LY)

Name: Rabbit Anti-SNX17 Recombinant Antibody (E8F8Y)
SKU: CBMAB-CP2531-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Rabbit

Clone

E8F8Y

Application

Immunogen

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asn54 of human SNX17 protein.

Specificity

Human, Mouse, Rat, Monkey

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

100 µg/ml BSA, 50% glycerol

Preservative

0.02% sodium azide

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Sorting Nexin 17

Introduction

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012]

Entrez Gene ID

Human	9784
Mouse	266781
Rat	298836
Monkey	701614

UniProt ID

Human	Q15036
Mouse	Q8BVL3
Rat	Q6AYS6
Monkey	F7H9A0

Alternative Names

Sorting Nexin 17; KIAA0064;

Function

Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (PubMed:15121882, PubMed:15769472).
Binds to NPxY sequences in the cytoplasmic tails of target cargos (PubMed:21512128).
Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (PubMed:28892079, PubMed:22492727).
Also required for maintenance of normal cell surface levels of APP and LRP1 (PubMed:16712798, PubMed:19005208).
Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:16712798).

Biological Process

Biological Process aorta developmentIEA:Ensembl
Biological Process cardiac septum developmentIEA:Ensembl
Biological Process cholesterol catabolic process1 PublicationIC:UniProtKB
Biological Process coronary vasculature developmentIEA:Ensembl
Biological Process endocytic recyclingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endosomal transport1 PublicationNAS:UniProtKB
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process kidney developmentIEA:Ensembl
Biological Process receptor-mediated endocytosisIEA:Ensembl
Biological Process regulation of endocytosis1 PublicationNAS:UniProtKB
Biological Process signal transductionIEA:InterPro

Cellular Location

Cytoplasm
Early endosome
Cytoplasmic vesicle membrane

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-SNX17 Recombinant Antibody (CBXS-2823) (CAT#: CBMAB-S5573-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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