SNX17

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012]

Full Name

Sorting Nexin 17

Function

Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (PubMed:15121882, PubMed:15769472).
Binds to NPxY sequences in the cytoplasmic tails of target cargos (PubMed:21512128).
Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (PubMed:28892079, PubMed:22492727).
Also required for maintenance of normal cell surface levels of APP and LRP1 (PubMed:16712798, PubMed:19005208).
Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:16712798).

Biological Process

Biological Process aorta developmentIEA:Ensembl
Biological Process cardiac septum developmentIEA:Ensembl
Biological Process cholesterol catabolic process1 PublicationIC:UniProtKB
Biological Process coronary vasculature developmentIEA:Ensembl
Biological Process endocytic recyclingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endosomal transport1 PublicationNAS:UniProtKB
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process kidney developmentIEA:Ensembl
Biological Process receptor-mediated endocytosisIEA:Ensembl
Biological Process regulation of endocytosis1 PublicationNAS:UniProtKB
Biological Process signal transductionIEA:InterPro

Cellular Location

Cytoplasm
Early endosome
Cytoplasmic vesicle membrane