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Mouse Anti-SNX18 Recombinant Antibody (CBXS-2206) (CBMAB-S4968-CQ)

This product is a mouse antibody that recognizes SNX18. The antibody CBXS-2206 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all SNX18 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-2206
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Sorting Nexin 18
Introduction
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a SH3 domain. Multiple transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
112574
UniProt ID
Q96RF0
Alternative Names
Sorting Nexin 18; Sorting Nexin Associated Golgi Protein 1; Sorting Nexin-Associated Golgi Protein 1; SH3 And PX Domain-Containing Protein 3B; SH3PXD3B; SNAG1; Sorting Nexin-18; SH3PX2;
Function
Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis (PubMed:20427313, PubMed:18411244, PubMed:21048941, PubMed:22718350).
Required for efficient progress through mitosis and cytokinesis (PubMed:22718350).
Required for normal formation of the cleavage furrow at the end of mitosis (PubMed:22718350).
Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis (PubMed:20427313).
Plays a role in macropinocytosis (PubMed:21048941).
Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation (PubMed:18411244).
Stimulates the GTPase activity of DNM2 (PubMed:20427313).
Promotes DNM2 location at the plasma membrane (PubMed:20427313).
Together with DNM2, involved in autophagosome assembly by regulating trafficking from recycling endosomes of phospholipid scramblase ATG9A (PubMed:29437695).
Biological Process
Biological Process cleavage furrow formationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endocytosisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process endosomal transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mitotic cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process plasma membrane tubulationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of autophagosome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein transportManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Endomembrane system
Endosome membrane
Recycling endosome membrane
Cell membrane
Cytoplasmic vesicle membrane
Localized at sites of endocytosis at the cell membrane (PubMed:18411244).
Detected on newly formed macropinosomes (PubMed:21048941).
Partially colocalized with clathrin and dynamin at the cell membrane (PubMed:20427313).
Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation (PubMed:18411244).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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