SNX18

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a SH3 domain. Multiple transcript variants encoding different isoforms have been found for this gene.

Full Name

Sorting Nexin 18

Function

Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis (PubMed:20427313, PubMed:18411244, PubMed:21048941, PubMed:22718350).
Required for efficient progress through mitosis and cytokinesis (PubMed:22718350).
Required for normal formation of the cleavage furrow at the end of mitosis (PubMed:22718350).
Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis (PubMed:20427313).
Plays a role in macropinocytosis (PubMed:21048941).
Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation (PubMed:18411244).
Stimulates the GTPase activity of DNM2 (PubMed:20427313).
Promotes DNM2 location at the plasma membrane (PubMed:20427313).
Together with DNM2, involved in autophagosome assembly by regulating trafficking from recycling endosomes of phospholipid scramblase ATG9A (PubMed:29437695).

Biological Process

Biological Process cleavage furrow formationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endocytosisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process endosomal transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mitotic cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process plasma membrane tubulationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of autophagosome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein transportManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Endomembrane system
Endosome membrane
Recycling endosome membrane
Cell membrane
Cytoplasmic vesicle membrane
Localized at sites of endocytosis at the cell membrane (PubMed:18411244).
Detected on newly formed macropinosomes (PubMed:21048941).
Partially colocalized with clathrin and dynamin at the cell membrane (PubMed:20427313).
Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation (PubMed:18411244).