Sign in or Register   Sign in or Register
  |  

Mouse Anti-SNX9 Recombinant Antibody (CBXS-3876) (CBMAB-S1145-CQ)

This product is a mouse antibody that recognizes SNX9. The antibody CBXS-3876 can be used for immunoassay techniques such as: FC, IF, IHC, IHC-P, WB.
See all SNX9 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Dog, Monkey, Rat
Clone
CBXS-3876
Antibody Isotype
IgG1
Application
FC, IF, IHC, IHC-P, WB

Basic Information

Immunogen
Recombinant full length human SNX9(NP_057308)
Specificity
Human, Dog, Monkey, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Sorting Nexin 9
Introduction
This gene encodes a member of the sorting nexin family. Members of this family contain a phosphoinositide binding domain, and are involved in intracellular trafficking. The encoded protein does not contain a coiled coil region, like some family members, but does contain a SRC homology domain near its N-terminus. The encoded protein is reported to have a variety of interaction partners, including of adaptor protein 2, dynamin, tyrosine kinase non-receptor 2, Wiskott-Aldrich syndrome-like, and ARP3 actin-related protein 3. The encoded protein is implicated in several stages of intracellular trafficking, including endocytosis, macropinocytosis, and F-actin nucleation.
Entrez Gene ID
Human51429
Monkey706016
Rat683687
Dog476254
UniProt ID
HumanQ9Y5X1
MonkeyF7DMQ2
RatB0BNM3
DogA0A8I3MD92
Alternative Names
Sorting Nexin 9; SH3 And PX Domain-Containing Protein 3A; SH3 And PX Domain-Containing Protein 1; SH3PXD3A; SH3PX1; Wiskott-Aldrich Syndrome Protein (WASP) Interactor Protein;
Function
Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate.
Biological Process
Biological Process cleavage furrow formationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endosomal transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process intracellular protein transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process lipid tube assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process mitotic cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process plasma membrane tubulationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of actin filament polymerizationISS:UniProtKB
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of membrane protein ectodomain proteolysisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of protein kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein-containing complex assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process receptor-mediated endocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasmic vesicle membrane
Cell membrane
Cytoplasmic vesicle, clathrin-coated vesicle
Golgi apparatus, trans-Golgi network
Cell projection, ruffle
Cytoplasm
Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation. Colocalizes with the actin cytoskeleton at the cell membrane.
PTM
Ubiquitinated by ITCH.
Phosphorylated on tyrosine residues by TNK2. Phosphorylation promotes its activity in the degradation of EGFR.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-SNX9 Recombinant Antibody (CBXS-3876)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare