SNX9

This gene encodes a member of the sorting nexin family. Members of this family contain a phosphoinositide binding domain, and are involved in intracellular trafficking. The encoded protein does not contain a coiled coil region, like some family members, but does contain a SRC homology domain near its N-terminus. The encoded protein is reported to have a variety of interaction partners, including of adaptor protein 2, dynamin, tyrosine kinase non-receptor 2, Wiskott-Aldrich syndrome-like, and ARP3 actin-related protein 3. The encoded protein is implicated in several stages of intracellular trafficking, including endocytosis, macropinocytosis, and F-actin nucleation.

Full Name

Sorting Nexin 9

Function

Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate.

Biological Process

Biological Process cleavage furrow formationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endosomal transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process intracellular protein transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process lipid tube assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process mitotic cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process plasma membrane tubulationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of actin filament polymerizationISS:UniProtKB
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of membrane protein ectodomain proteolysisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of protein kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein-containing complex assemblyManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process receptor-mediated endocytosisManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasmic vesicle membrane
Cell membrane
Cytoplasmic vesicle, clathrin-coated vesicle
Golgi apparatus, trans-Golgi network
Cell projection, ruffle
Cytoplasm
Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation. Colocalizes with the actin cytoskeleton at the cell membrane.

PTM

Ubiquitinated by ITCH.
Phosphorylated on tyrosine residues by TNK2. Phosphorylation promotes its activity in the degradation of EGFR.