Mouse Anti-SOCS1 (AA 2-78) Recombinant Antibody (CBXS-5556) (CBMAB-S2763-CQ)

Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity (PubMed:9341160).
Regulates IFN-gamma (IFNG)-mediated sensory neuron survival (By similarity).
Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11278610, PubMed:11313480).
Biological Process cytokine-mediated signaling pathwayISS:UniProtKB
Biological Process fat cell differentiationIEA:Ensembl
Biological Process intracellular signal transductionIEA:InterPro
Biological Process macrophage differentiationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of CD8-positive, alpha-beta T cell differentiationISS:UniProtKB
Biological Process negative regulation of insulin receptor signaling pathwayISS:UniProtKB
Biological Process negative regulation of receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of tyrosine phosphorylation of STAT proteinManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of CD4-positive, alpha-beta T cell differentiationISS:UniProtKB
Biological Process positive regulation of regulatory T cell differentiationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process protein ubiquitinationIEA:UniProtKB-UniPathway
Biological Process receptor signaling pathway via JAK-STATIEA:Ensembl
Biological Process regulation of activation of Janus kinase activityIEA:Ensembl
Biological Process regulation of cytokine productionIEA:Ensembl
Biological Process regulation of interferon-gamma-mediated signaling pathwayIEA:InterPro
Biological Process regulation of protein phosphorylationISS:UniProtKB
Cytoplasmic vesicle
Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.
An autosomal dominant, autoinflammatory disorder with incomplete penetrance characterized by autoimmune cytopenia, hemolytic anemia, thrombocytopenia, and lymphadenopathy. Additional variable features may include autoimmune thyroiditis, psoriasis or eczema, nephritis, hepatitis, and symptoms of systemic lupus erythematosus. Immunodeficiency is present in some patients. Disease onset is usually in the first decades of life, although later onset has been reported.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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