SOCS1

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.

suppressor of cytokine signaling 1

Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF) (PubMed:32499645, PubMed:33087723).
Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity (PubMed:9341160).
Regulates IFN-gamma (IFNG)-mediated sensory neuron survival (By similarity).
Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11278610, PubMed:11313480).

Biological Process cellular response to amino acid stimulusIEA:Ensembl
Biological Process cytokine-mediated signaling pathwayISS:UniProtKB
Biological Process fat cell differentiationIEA:Ensembl
Biological Process intracellular signal transductionIEA:InterPro
Biological Process macrophage differentiationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of CD8-positive, alpha-beta T cell differentiationISS:UniProtKB
Biological Process negative regulation of insulin receptor signaling pathwayISS:UniProtKB
Biological Process negative regulation of receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of tyrosine phosphorylation of STAT proteinManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of CD4-positive, alpha-beta T cell differentiationISS:UniProtKB
Biological Process positive regulation of regulatory T cell differentiationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process protein ubiquitinationIEA:UniProtKB-UniPathway
Biological Process receptor signaling pathway via JAK-STATIEA:Ensembl
Biological Process regulation of activation of Janus kinase activityIEA:Ensembl
Biological Process regulation of cytokine productionIEA:Ensembl
Biological Process regulation of interferon-gamma-mediated signaling pathwayIEA:InterPro
Biological Process regulation of protein phosphorylationISS:UniProtKB

Nucleus
Cytoplasmic vesicle
Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.

Autoinflammatory syndrome, familial, with or without immunodeficiency (AISIMD):
An autosomal dominant, autoinflammatory disorder with incomplete penetrance characterized by autoimmune cytopenia, hemolytic anemia, thrombocytopenia, and lymphadenopathy. Additional variable features may include autoimmune thyroiditis, psoriasis or eczema, nephritis, hepatitis, and symptoms of systemic lupus erythematosus. Immunodeficiency is present in some patients. Disease onset is usually in the first decades of life, although later onset has been reported.