Mouse Anti-SOCS3 Recombinant Antibody (CBT4817) (V2LY-0625-LY1828)

Name: Mouse Anti-SOCS3 Recombinant Antibody (CBT4817)
SKU: V2LY-0625-LY1828
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-SOCS3 Recombinant Antibody (CBT4817) (V2LY-0625-LY1828) in ELISA

Mouse Anti-SOCS3 Recombinant Antibody (CBT4817) (V2LY-0625-LY1828) in WB

Mouse Anti-SOCS3 Recombinant Antibody (CBT4817) (V2LY-0625-LY1828) in IF

Mouse Anti-SOCS3 Recombinant Antibody (CBT4817) (V2LY-0625-LY1828) in FC

Mouse Anti-SOCS3 Recombinant Antibody (CBT4817) (V2LY-0625-LY1828) in IHC

Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBT4817

Application

IHC, ICC, FC

Immunogen

Purified recombinant fragment of human SOCS3 (AA: 1-225) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
IHC-P	1:200-1:1,000
ICC	1:200-1:1,000
FC	1:200-1:400
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Suppressor Of Cytokine Signaling 3

Entrez Gene ID

9021

Function

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including IL6ST/gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity and regulates IL6 signaling. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (By similarity).
Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820).

Biological Process

Biological Process branching involved in labyrinthine layer morphogenesisIEA:Ensembl
Biological Process cell differentiationIEA:Ensembl
Biological Process cellular response to interleukin-17IEA:Ensembl
Biological Process cellular response to leukemia inhibitory factorIEA:Ensembl
Biological Process intracellular signal transductionIEA:InterPro
Biological Process negative regulation of apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of inflammatory responseIEA:Ensembl
Biological Process negative regulation of insulin receptor signaling pathwayIEA:Ensembl
Biological Process negative regulation of receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of tyrosine phosphorylation of STAT proteinManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process placenta blood vessel developmentIEA:Ensembl
Biological Process positive regulation of cell differentiationIEA:Ensembl
Biological Process protein ubiquitinationIEA:UniProtKB-UniPathway
Biological Process receptor signaling pathway via JAK-STATIEA:InterPro

Cellular Location

cytosol
phosphatidylinositol 3-kinase complex

Involvement in disease

There is some evidence that SOCS3 may be a susceptibility gene for atopic dermatitis linked to 17q25. SOCS3 messenger RNA is significantly more highly expressed in skin from patients with atopic dermatitis than in skin from healthy controls. Furthermore, a genetic association between atopic dermatitis and a haplotype in the SOCS3 gene has been found in two independent groups of patients.

PTM

Phosphorylated on tyrosine residues after stimulation by the cytokines, IL-2, EPO or IGF1.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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