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SOCS3

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq, Jul 2008]
Full Name
Suppressor Of Cytokine Signaling 3
Function
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including IL6ST/gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity and regulates IL6 signaling. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (By similarity).
Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820).
Biological Process
Biological Process branching involved in labyrinthine layer morphogenesisIEA:Ensembl
Biological Process cell differentiationIEA:Ensembl
Biological Process cellular response to interleukin-17IEA:Ensembl
Biological Process cellular response to leukemia inhibitory factorIEA:Ensembl
Biological Process intracellular signal transductionIEA:InterPro
Biological Process negative regulation of apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of inflammatory responseIEA:Ensembl
Biological Process negative regulation of insulin receptor signaling pathwayIEA:Ensembl
Biological Process negative regulation of receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process negative regulation of tyrosine phosphorylation of STAT proteinManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process placenta blood vessel developmentIEA:Ensembl
Biological Process positive regulation of cell differentiationIEA:Ensembl
Biological Process protein ubiquitinationIEA:UniProtKB-UniPathway
Biological Process receptor signaling pathway via JAK-STATIEA:InterPro
Cellular Location
cytosol
phosphatidylinositol 3-kinase complex
Involvement in disease
There is some evidence that SOCS3 may be a susceptibility gene for atopic dermatitis linked to 17q25. SOCS3 messenger RNA is significantly more highly expressed in skin from patients with atopic dermatitis than in skin from healthy controls. Furthermore, a genetic association between atopic dermatitis and a haplotype in the SOCS3 gene has been found in two independent groups of patients.
PTM
Phosphorylated on tyrosine residues after stimulation by the cytokines, IL-2, EPO or IGF1.

Anti-SOCS3 antibodies

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Target: SOCS3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: SOC-25
Application*: WB
Target: SOCS3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-3334
Application*: E, WB
Target: SOCS3
Host: Mouse
Specificity: Human
Clone: CBXS-2959
Application*: E
Target: SOCS3
Host: Mouse
Specificity: Human
Clone: CBXS-2894
Application*: E
Target: SOCS3
Host: Mouse
Specificity: Human
Clone: CBXS-2786
Application*: E
Target: SOCS3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-0632
Application*: E, WB, P
Target: SOCS3
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBXS-0633
Application*: WB
Target: SOCS3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-0634
Application*: SE, E
Target: SOCS3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYC-A1058
Application*: WB, IC, P, C, E
Target: SOCS3
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBYC-A1059
Application*: WB, IC, P, C, E
Target: SOCS3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1E4
Application*: SE, E
Target: SOCS3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2E5
Application*: IH, E
Target: SOCS3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1F6
Application*: SE, E
Target: SOCS3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2H2
Application*: SE, E
Target: SOCS3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBXS-1844
Application*: WB, IC
Target: SOCS3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5844
Application*: F, IF, IH, WB
Target: SOCS3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5881
Application*: F, IF, P, WB
Target: SOCS3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: CBXS-3863
Application*: E, WB
Target: SOCS3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXS-4058
Application*: E
Target: SOCS3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-5148
Application*: IF, WB
Target: SOCS3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-5159
Application*: F, IF, P, WB
Target: SOCS3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5208
Application*: IF, WB
Target: SOCS3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-5210
Application*: F, IF, WB
Target: SOCS3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-5288
Application*: F, IF, P, WB
Target: SOCS3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXC-0693
Application*: E, F
Target: SOCS3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: SO1
Application*: WB
Target: SOCS3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3653
Application*: F, IF, WB
Target: SOCS3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-3743
Application*: P, WB
Target: SOCS3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3782
Application*: WB
Target: SOCS3
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-4841
Application*: WB, F, IH, IF, P
Target: SOCS3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: D6E1T
Application*: WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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