Sign in or Register   Sign in or Register
  |  

Mouse Anti-SOCS5 Recombinant Antibody (CBXS-4472) (CBMAB-S1714-CQ)

This product is a mouse antibody that recognizes SOCS5. The antibody CBXS-4472 can be used for immunoassay techniques such as: ELISA, IHC-P, WB.
See all SOCS5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4472
Antibody Isotype
IgG1, κ
Application
ELISA, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Suppressor Of Cytokine Signaling 5
Introduction
The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported.
Entrez Gene ID
9655
UniProt ID
O75159
Alternative Names
Suppressor Of Cytokine Signaling 5; Cytokine-Inducible SH2-Containing Protein 5; Cytokine-Inducible SH2 Protein 6; SOCS-5; Cish5; CIS-6; CISH6; CIS6; KIAA0671;
Function
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.
Biological Process
Biological Process cellular response to low-density lipoprotein particle stimulusIEA:Ensembl
Biological Process cytokine-mediated signaling pathwayISS:UniProtKB
Biological Process epidermal growth factor receptor signaling pathwayIEA:Ensembl
Biological Process intracellular signal transductionIEA:InterPro
Biological Process negative regulation of epidermal growth factor-activated receptor activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of inflammatory responseIEA:Ensembl
Biological Process negative regulation of interleukin-6 productionIEA:Ensembl
Biological Process negative regulation of monocyte chemotactic protein-1 productionIEA:Ensembl
Biological Process negative regulation of signal transduction1 PublicationNAS:UniProtKB
Biological Process negative regulation of T-helper 2 cell differentiationISS:UniProtKB
Biological Process phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of proteasomal ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of T-helper 1 cell differentiationISS:UniProtKB
Biological Process protein ubiquitinationIEA:UniProtKB-UniPathway
Biological Process receptor signaling pathway via JAK-STATIEA:InterPro
Biological Process vascular endothelial cell response to fluid shear stressIEA:Ensembl
Cellular Location
cytosol
phosphatidylinositol 3-kinase complex
PTM
Phosphorylated. Phosphorylation is induced by EGF.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-SOCS5 Recombinant Antibody (CBXS-4472)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare