SOCS5

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported.

Full Name

Suppressor Of Cytokine Signaling 5

Function

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.

Biological Process

Biological Process cellular response to low-density lipoprotein particle stimulusIEA:Ensembl
Biological Process cytokine-mediated signaling pathwayISS:UniProtKB
Biological Process epidermal growth factor receptor signaling pathwayIEA:Ensembl
Biological Process intracellular signal transductionIEA:InterPro
Biological Process negative regulation of epidermal growth factor-activated receptor activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of inflammatory responseIEA:Ensembl
Biological Process negative regulation of interleukin-6 productionIEA:Ensembl
Biological Process negative regulation of monocyte chemotactic protein-1 productionIEA:Ensembl
Biological Process negative regulation of signal transduction1 PublicationNAS:UniProtKB
Biological Process negative regulation of T-helper 2 cell differentiationISS:UniProtKB
Biological Process phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of proteasomal ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of T-helper 1 cell differentiationISS:UniProtKB
Biological Process protein ubiquitinationIEA:UniProtKB-UniPathway
Biological Process receptor signaling pathway via JAK-STATIEA:InterPro
Biological Process vascular endothelial cell response to fluid shear stressIEA:Ensembl

Cellular Location

cytosol
phosphatidylinositol 3-kinase complex

PTM

Phosphorylated. Phosphorylation is induced by EGF.