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Mouse Anti-SOCS6 Recombinant Antibody (CBXS-1847) (CBMAB-S4650-CQ)

This product is a mouse antibody that recognizes SOCS6. The antibody CBXS-1847 can be used for immunoassay techniques such as: WB, ICC.
See all SOCS6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-1847
Antibody Isotype
IgG2b
Application
WB, ICC

Basic Information

Immunogen
Recombinant human SOCS-6, Met1-Tyr535, Accession # O14544
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Suppressor Of Cytokine Signaling 6
Introduction
The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines.
Entrez Gene ID
9306
UniProt ID
O14544
Alternative Names
Suppressor Of Cytokine Signaling 6; Suppressor Of Cytokine Signaling 4; Cytokine-Inducible SH2 Protein 4; SOCS-4; SOCS-6; SOCS4; CIS-4;
Function
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor.
Biological Process
Biological Process defense responseManual Assertion Based On ExperimentTAS:ProtInc
Biological Process intracellular signal transductionIEA:InterPro
Biological Process negative regulation of signal transductionIEA:UniProtKB-KW
Biological Process negative regulation of T cell activationIEA:Ensembl
Biological Process phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process proteasomal protein catabolic processManual Assertion Based On ExperimentIMP:MGI
Biological Process protein ubiquitinationIEA:UniProtKB-UniPathway
Biological Process receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentTAS:ProtInc
Biological Process regulation of growthIEA:Ensembl
Cellular Location
cytoplasm
cytosol
immunological synapse
phosphatidylinositol 3-kinase complex
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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