SOCS6

The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]

Full Name

Suppressor Of Cytokine Signaling 6

Function

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor.

Biological Process

Biological Process defense responseManual Assertion Based On ExperimentTAS:ProtInc
Biological Process intracellular signal transductionIEA:InterPro
Biological Process negative regulation of signal transductionIEA:UniProtKB-KW
Biological Process negative regulation of T cell activationIEA:Ensembl
Biological Process phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process proteasomal protein catabolic processManual Assertion Based On ExperimentIMP:MGI
Biological Process protein ubiquitinationIEA:UniProtKB-UniPathway
Biological Process receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentTAS:ProtInc
Biological Process regulation of growthIEA:Ensembl

Cellular Location

cytoplasm
cytosol
immunological synapse
phosphatidylinositol 3-kinase complex