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Mouse Anti-SOHLH2 Recombinant Antibody (CBXS-4027) (CBMAB-S1288-CQ)

This product is a mouse antibody that recognizes SOHLH2. The antibody CBXS-4027 can be used for immunoassay techniques such as: ELISA, IP, WB.
See all SOHLH2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4027
Antibody Isotype
IgG2a, κ
Application
ELISA, IP, WB

Basic Information

Immunogen
SOHLH2 (AAH25383, 1 a.a.-225 a.a) Full length recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Spermatogenesis And Oogenesis Specific Basic Helix-Loop-Helix 2
Introduction
This gene encodes one of testis-specific transcription factors which are essential for spermatogenesis, oogenesis and folliculogenesis. This gene is located on chromosome 13. The proteins encoded by this gene and another testis-specific transcription factor, SOHLH1, can form heterodimers, in addition to homodimers. There is a read-through locus (GeneID: 100526761) that shares sequence identity with this gene and the upstream CCDC169 (GeneID: 728591). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
UniProt ID
Alternative Names
Spermatogenesis And Oogenesis Specific Basic Helix-Loop-Helix 2; Spermatogenesis Associated 28; TEB1; Spermatogenesis- And Oogenesis-Specific Basic Helix-Loop-Helix-Containing Protein 2; Testicular Secretory Protein Li 50; Testicular Secretory Protein Li 51; SPATA28; BHLHe81; SOSF2;
Function
Transcription regulator of both male and female germline differentiation. Suppresses genes involved in spermatogonial stem cells maintenance, and induces genes important for spermatogonial differentiation. Coordinates oocyte differentiation without affecting meiosis I (By similarity).
Biological Process
Biological Process cell differentiationISS:UniProtKB
Biological Process oocyte differentiationISS:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process spermatogenesisISS:UniProtKB
Cellular Location
Nucleus
Cytoplasm
Translocates from the cytoplasm into the nucleus and the translocation is dependent on SOHLH1 expression.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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