SOHLH2

This gene encodes one of testis-specific transcription factors which are essential for spermatogenesis, oogenesis and folliculogenesis. This gene is located on chromosome 13. The proteins encoded by this gene and another testis-specific transcription factor, SOHLH1, can form heterodimers, in addition to homodimers. There is a read-through locus (GeneID: 100526761) that shares sequence identity with this gene and the upstream CCDC169 (GeneID: 728591). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Full Name

Spermatogenesis And Oogenesis Specific Basic Helix-Loop-Helix 2

Function

Transcription regulator of both male and female germline differentiation. Suppresses genes involved in spermatogonial stem cells maintenance, and induces genes important for spermatogonial differentiation. Coordinates oocyte differentiation without affecting meiosis I (By similarity).

Biological Process

Biological Process cell differentiationISS:UniProtKB
Biological Process oocyte differentiationISS:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process spermatogenesisISS:UniProtKB

Cellular Location

Nucleus
Cytoplasm
Translocates from the cytoplasm into the nucleus and the translocation is dependent on SOHLH1 expression.