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Mouse Anti-SOX3 Recombinant Antibody (CBXS-1751) (CBMAB-S4575-CQ)

This product is a mouse antibody that recognizes SOX3. The antibody CBXS-1751 can be used for immunoassay techniques such as: ICC.
See all SOX3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-1751
Antibody Isotype
IgG2a
Application
ICC

Basic Information

Immunogen
Recombinant human SOX3, Met1-Leu230, Accession # P41225
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SOX3
Introduction
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene have been associated with X-linked cognitive disability with growth hormone deficiency.
Entrez Gene ID
6658
UniProt ID
P41225
Alternative Names
SRY-Box 3; SRY (Sex Determining Region Y)-Box 3; Transcription Factor SOX-3; Panhypopituitarism; SRY Box 3; GHDX;
Function
Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity).
Biological Process
Biological Process anatomical structure morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process central nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process face developmentISS:UniProtKB
Biological Process hypothalamus developmentISS:UniProtKB
Biological Process negative regulation of neuron differentiationISS:UniProtKB
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process pituitary gland developmentISS:UniProtKB
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sensory organ developmentISS:UniProtKB
Biological Process sex determinationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Nucleus
Involvement in disease
Panhypopituitarism X-linked (PHPX):
Affected individuals have absent infundibulum, anterior pituitary hypoplasia, and ectopic posterior pituitary.
Intellectual developmental disorder, X-linked, with isolated growth hormone deficiency (MRXGH):
A disorder characterized by the association of variable degrees of intellectual disability with panhypopituitarism, variable combinations of hypothyroidism, delayed pubertal development, and short stature due to growth hormone deficiency.
46,XX sex reversal 3 (SRXX3):
A condition in which male gonads develop in a genetic female (female to male sex reversal).
Hypoparathyroidism, X-linked (HYPX):
An X-linked form of true hypoparathyroidism characterized by neonatal or infantile onset and absence of parathyroid glands. Clinical features are hypocalcemia, hyperphosphatemia, seizures, tetany and cramps.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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