Mouse Anti-SOX8 Monoclonal Antibody (1F4) (CBMAB-0165-LY)

Mouse

Human

1F4

IgG2b

IP, MA, WB

Recombinant peptide (Full Length)

Human

IgG2b

Monoclonal

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Supernatant

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

SRY (sex determining region Y)-box 8

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the cognitive disability found in an alpha-thalassemia-related syndrome (ART-16). This protein is also highly expressed in the majority of human hepatocellular carcinomas and promotes cellular proliferation and enhanced tumor growth. This protein may play a role in central nervous system, limb and facial development.

Transcription factor that may play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3' (By similarity).

Biological Process adipose tissue developmentISS:UniProtKB
Biological Process astrocyte fate commitmentIEA:Ensembl
Biological Process cell fate commitmentISS:UniProtKB
Biological Process cell maturationIEA:Ensembl
Biological Process enteric nervous system developmentISS:UniProtKB
Biological Process fat cell differentiationISS:UniProtKB
Biological Process in utero embryonic developmentISS:UniProtKB
Biological Process male gonad developmentISS:UniProtKB
Biological Process metanephric nephron tubule formationISS:UniProtKB
Biological Process morphogenesis of a branching epitheliumISS:UniProtKB
Biological Process morphogenesis of an epitheliumManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of apoptotic processISS:UniProtKB
Biological Process negative regulation of DNA-templated transcriptionISS:UniProtKB
Biological Process negative regulation of myoblast differentiationISS:UniProtKB
Biological Process negative regulation of photoreceptor cell differentiationIEA:Ensembl
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neural crest cell developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neural crest cell migrationISS:UniProtKB
Biological Process oligodendrocyte differentiationISS:UniProtKB
Biological Process osteoblast differentiationISS:UniProtKB
Biological Process peripheral nervous system developmentISS:UniProtKB
Biological Process positive regulation of branching involved in ureteric bud morphogenesisISS:UniProtKB
Biological Process positive regulation of DNA-templated transcriptionISS:UniProtKB
Biological Process positive regulation of gene expressionIEA:Ensembl
Biological Process positive regulation of gliogenesisISS:UniProtKB
Biological Process positive regulation of kidney developmentISS:UniProtKB
Biological Process positive regulation of osteoblast proliferationISS:UniProtKB
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of hormone levelsISS:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process renal vesicle inductionISS:UniProtKB
Biological Process retina development in camera-type eyeISS:UniProtKB
Biological Process retinal rod cell differentiationISS:UniProtKB
Biological Process Sertoli cell developmentISS:UniProtKB
Biological Process signal transductionISS:UniProtKB
Biological Process skeletal muscle cell differentiationIEA:Ensembl
Biological Process spermatogenesisISS:UniProtKB
Biological Process ureter morphogenesisISS:UniProtKB

Nucleus