Mouse Anti-SOX8 Monoclonal Antibody (2B9) (CBMAB-0166-LY)

SRY (sex determining region Y)-box 8

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the cognitive disability found in an alpha-thalassemia-related syndrome (ART-16). This protein is also highly expressed in the majority of human hepatocellular carcinomas and promotes cellular proliferation and enhanced tumor growth. This protein may play a role in central nervous system, limb and facial development.

Transcription factor that may play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3' (By similarity).

Biological Process adipose tissue developmentISS:UniProtKB
Biological Process astrocyte fate commitmentIEA:Ensembl
Biological Process cell fate commitmentISS:UniProtKB
Biological Process cell maturationIEA:Ensembl
Biological Process enteric nervous system developmentISS:UniProtKB
Biological Process fat cell differentiationISS:UniProtKB
Biological Process in utero embryonic developmentISS:UniProtKB
Biological Process male gonad developmentISS:UniProtKB
Biological Process metanephric nephron tubule formationISS:UniProtKB
Biological Process morphogenesis of a branching epitheliumISS:UniProtKB
Biological Process morphogenesis of an epitheliumManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of apoptotic processISS:UniProtKB
Biological Process negative regulation of DNA-templated transcriptionISS:UniProtKB
Biological Process negative regulation of myoblast differentiationISS:UniProtKB
Biological Process negative regulation of photoreceptor cell differentiationIEA:Ensembl
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neural crest cell developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neural crest cell migrationISS:UniProtKB
Biological Process oligodendrocyte differentiationISS:UniProtKB
Biological Process osteoblast differentiationISS:UniProtKB
Biological Process peripheral nervous system developmentISS:UniProtKB
Biological Process positive regulation of branching involved in ureteric bud morphogenesisISS:UniProtKB
Biological Process positive regulation of DNA-templated transcriptionISS:UniProtKB
Biological Process positive regulation of gene expressionIEA:Ensembl
Biological Process positive regulation of gliogenesisISS:UniProtKB
Biological Process positive regulation of kidney developmentISS:UniProtKB
Biological Process positive regulation of osteoblast proliferationISS:UniProtKB
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of hormone levelsISS:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process renal vesicle inductionISS:UniProtKB
Biological Process retina development in camera-type eyeISS:UniProtKB
Biological Process retinal rod cell differentiationISS:UniProtKB
Biological Process Sertoli cell developmentISS:UniProtKB
Biological Process signal transductionISS:UniProtKB
Biological Process skeletal muscle cell differentiationIEA:Ensembl
Biological Process spermatogenesisISS:UniProtKB
Biological Process ureter morphogenesisISS:UniProtKB

Nucleus