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Mouse Anti-SP140 Recombinant Antibody (3F9) (CBMAB-A8498-LY)

The product is antibody recognizes SP140. The antibody 3F9 immunoassay techniques such as: IHC, ELISA.
See all SP140 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3F9
Antibody Isotype
IgG2a, κ
Application
IHC, ELISA

Basic Information

Immunogen
SP140 (NP_009168.3, 504 a.a. ~ 612 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
SP140
Entrez Gene ID
11262
UniProt ID
Q13342
Alternative Names
LYSP100; LYSP100-A; LYSP100-B; MGC126440
Function
Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body (PubMed:8910577).
May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection (PubMed:8910577).
May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails (PubMed:24267382).
Biological Process
Biological Process defense responseManual Assertion Based On ExperimentTAS:ProtInc
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Nucleus, PML body
Cytoplasm
Localized to nuclear structures termed LANDS, for LYSp100-associated nuclear domains. LANDS are globular, electron-dense structures most often found in the nucleoplasm, but also found at the nuclear membrane and in the cytoplasm, suggesting that these structures may traffic between the cytoplasm and the nucleus (PubMed:8695863).
Also colocalizes with PML in a subset of PML nuclear bodies (PubMed:8910577).
PTM
Phosphorylation at Thr-726 promotes binding of PIN1 and subsequent isomerization of Pro-727.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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