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Mouse Anti-SP140 Recombinant Antibody (CBXS-0678) (CBMAB-S3615-CQ)

This product is a mouse antibody that recognizes SP140. The antibody CBXS-0678 can be used for immunoassay techniques such as: ELISA, IHC-P.
See all SP140 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-0678
Antibody Isotype
IgG2a, κ
Application
ELISA, IHC-P

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SP140
Introduction
This gene encodes a member of the SP100 family of proteins, which are share common domains including an N-terminal homogeneously staining region domain followed by a SP100/autoimmune regulator/NucP41/P75/deformed epidermal autoregulatory factor domain, a plant homeobox zinc finger, and a bromodomain. The encoded protein is interferon-inducible and is expressed at high levels in the nuclei of leukocytes. Variants of this gene have been associated with multiple sclerosis, Crohn's disease, and chronic lymphocytic leukemia. Alternative splicing results in multiple variants.
Entrez Gene ID
11262
UniProt ID
Q13342
Alternative Names
SP140 Nuclear Body Protein; Lymphoid-Restricted Homolog Of Sp100; Nuclear Autoantigen Sp-140; Speckled 140 KDa; LYSP100; Lymphoid-Specific SP100 Homolog; Nuclear Body Protein SP140; LYSP100-A; LYSP100-B;
Function
Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body (PubMed:8910577).
May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection (PubMed:8910577).
May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails (PubMed:24267382).
Biological Process
Biological Process defense responseManual Assertion Based On ExperimentTAS:ProtInc
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Nucleus, PML body
Cytoplasm
Localized to nuclear structures termed LANDS, for LYSp100-associated nuclear domains. LANDS are globular, electron-dense structures most often found in the nucleoplasm, but also found at the nuclear membrane and in the cytoplasm, suggesting that these structures may traffic between the cytoplasm and the nucleus (PubMed:8695863).
Also colocalizes with PML in a subset of PML nuclear bodies (PubMed:8910577).
PTM
Phosphorylation at Thr-726 promotes binding of PIN1 and subsequent isomerization of Pro-727.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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