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Mouse Anti-SP7 Recombinant Antibody (CBXO-0342) (CBMAB-O0662-CQ)

This product is a mouse antibody that recognizes SP7. The antibody CBXO-0342 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all SP7 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBXO-0342
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Sp7 transcription factor
Introduction
This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.
Entrez Gene ID
Human121340
Mouse170574
Rat300260
UniProt ID
HumanQ8TDD2
MouseQ8VI67
RatQ6IMK1
Alternative Names
Sp7 Transcription Factor; Zinc Finger Protein Osterix; OSX; Transcription Factor Sp7; Osterix; OI11; OI12
Function
Transcriptional activator essential for osteoblast differentiation (PubMed:23457570).
Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (By similarity).
Biological Process
Biological Process cellular response to zinc ion starvationIEA:Ensembl
Biological Process cementum mineralizationIEA:Ensembl
Biological Process diphosphate metabolic processIEA:Ensembl
Biological Process hematopoietic stem cell differentiationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process osteoblast differentiationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of stem cell differentiationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process regulation of hydrolase activityIEA:Ensembl
Biological Process regulation of transcription by RNA polymerase IIBy SimilarityISS:BHF-UCL
Biological Process response to insulinIEA:Ensembl
Biological Process response to organic cyclic compoundIEA:Ensembl
Cellular Location
Nucleus
Involvement in disease
Osteogenesis imperfecta 12 (OI12):
A form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI12 is an autosomal recessive form characterized by recurrent fractures, mild bone deformations, generalized osteoporosis, delayed teeth eruption, no dentinogenesis imperfecta, normal hearing, and white sclerae.
PTM
Ubiquitination at leads to proteasomal degradation. SP7 is a short-live protein with an endogenous half-life of approximately 12 hours.
Propionylated. Depropionylation at Lys-371 by SIRT7 activates transcription factor activity and positively regulates bone formation by osteoblasts.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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