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Mouse Anti-SPA17 Recombinant Antibody (3B6) (CBMAB-A8517-LY)

The product is antibody recognizes SPA17. The antibody 3B6 immunoassay techniques such as: WB, ELISA.
See all SPA17 antibodies
Published Data
Fig.1 Immunohistochemistry and immunocytochemistry staining of HSp17 in epithelial ovarian carcinomas.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
3B6
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
SPA17 (NP_059121, 51 a.a. ~ 149 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
sperm autoantigenic protein 17
Introduction
This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22
Entrez Gene ID
53340
UniProt ID
Q15506
Alternative Names
SP17; SP17-1
Function
Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity).
Biological Process
Biological Process binding of sperm to zona pellucidaIEA:InterPro
Biological Process epithelial cilium movement involved in extracellular fluid movement1 PublicationNAS:BHF-UCL
Biological Process single fertilizationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process spermatogenesisManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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