SPA17

This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22
Full Name
sperm autoantigenic protein 17
Function
Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity).
Biological Process
Biological Process binding of sperm to zona pellucidaIEA:InterPro
Biological Process epithelial cilium movement involved in extracellular fluid movement1 PublicationNAS:BHF-UCL
Biological Process single fertilizationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process spermatogenesisManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Membrane
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Anti-SPA17 antibodies

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Mouse Anti-SPA17 Recombinant Antibody (3B6) (CBMAB-A8517-LY)

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Target: SPA17
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3B6
Application*: WB, E
Datasheet SDS

Rabbit Anti-SPA17 Recombinant Antibody (CBXS-1546) (CBMAB-S4395-CQ)

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Target: SPA17
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1546
Application*: IP, P
Datasheet SDS

Rabbit Anti-SPA17 Recombinant Antibody (CBXS-1223) (CBMAB-S4086-CQ)

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Target: SPA17
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBXS-1223
Application*: WB, IF
Datasheet SDS

Mouse Anti-SPA17 Recombinant Antibody (CBXS-5221) (CBMAB-S2438-CQ)

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Target: SPA17
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5221
Application*: WB
Datasheet SDS

Mouse Anti-SPA17 Recombinant Antibody (CBXS-4961) (CBMAB-S2183-CQ)

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Target: SPA17
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4961
Application*: WB
Datasheet SDS

Mouse Anti-SPA17 Recombinant Antibody (CBXS-4880) (CBMAB-S2103-CQ)

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Target: SPA17
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4880
Application*: WB
Datasheet SDS

Mouse Anti-SPA17 Recombinant Antibody (CBXS-4630) (CBMAB-S1869-CQ)

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Target: SPA17
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4630
Application*: WB
Datasheet SDS

Mouse Anti-SPA17 Recombinant Antibody (CBXS-4227) (CBMAB-S1479-CQ)

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Target: SPA17
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4227
Application*: WB
Datasheet SDS

Mouse Anti-SPA17 Recombinant Antibody (CBXS-4148) (CBMAB-S1401-CQ)

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Target: SPA17
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4148
Application*: WB
Datasheet SDS

Mouse Anti-SPA17 Recombinant Antibody (CBXS-4022) (CBMAB-S1283-CQ)

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Target: SPA17
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4022
Application*: WB
Datasheet SDS

Mouse Anti-SPA17 Recombinant Antibody (CBT4303) (V2LY-0625-LY1518)

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Target: SPA17
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4303
Application*: IH, F
Datasheet SDS

Mouse Anti-SPA17 Recombinant Antibody (CBT4439) (V2LY-0625-LY1443)

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Target: SPA17
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4439
Application*: IH, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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