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Recombinant Mouse Anti-SPAG1 Recombinant Antibody (10G1/2) (CBMAB-XB1057-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
10G1/2
Antibody Isotype
IgG
Application
IF, IP, WB

Basic Information

Immunogen
Synthetic peptide SPA-3 (sequence designed to avoid TPR motifs-KTAPFNKEKERRKIEIQEVNE)
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Sperm Associated Antigen 1
Introduction
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein.
Entrez Gene ID
6674
UniProt ID
Q07617
Alternative Names
Sperm Associated Antigen 1; Infertility-Related Sperm Protein Spag-1; HSD-3.8; TPR-Containing Protein Involved In Spermatogenesis; Tetratricopeptide Repeat-Containing Protein; Epididymis Secretory Protein Li 268; Sperm-Associated Antigen 1;
Function
May play a role in the cytoplasmic assembly of the ciliary dynein arms (By similarity).
May play a role in fertilization. Binds GTP and has GTPase activity.
Biological Process
Biological Process axonemal dynein complex assemblyISS:UniProtKB
Biological Process protein stabilization1 PublicationIC:ComplexPortal
Biological Process single fertilizationManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm
Dynein axonemal particle
Colocalizes with tubulin.
Involvement in disease
Ciliary dyskinesia, primary, 28 (CILD28):
A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. Patients may exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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