Mouse Anti-SPAG1 Recombinant Antibody (CBXS-3628) (CBMAB-S0211-CQ)

Name: Mouse Anti-SPAG1 Recombinant Antibody (CBXS-3628)
SKU: CBMAB-S0211-CQ
Rating: 5 (1 reviews)

See all SPAG1 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXS-3628

Application

WB, IF, IP

Immunogen

Synthetic peptide SPA-3 (sequence designed to avoid TPR motifs-KTAPFNKEKERRKIEIQEVNE)

Specificity

Human

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Sperm Associated Antigen 1

Introduction

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein.

Entrez Gene ID

6674

UniProt ID

Q07617

Alternative Names

Sperm Associated Antigen 1; Infertility-Related Sperm Protein Spag-1; HSD-3.8; TPR-Containing Protein Involved In Spermatogenesis; Tetratricopeptide Repeat-Containing Protein; Epididymis Secretory Protein Li 268; Sperm-Associated Antigen 1;

Function

May play a role in the cytoplasmic assembly of the ciliary dynein arms (By similarity).
May play a role in fertilization. Binds GTP and has GTPase activity.

Biological Process

Biological Process axonemal dynein complex assemblyISS:UniProtKB
Biological Process protein stabilization1 PublicationIC:ComplexPortal
Biological Process single fertilizationManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cytoplasm
Dynein axonemal particle
Colocalizes with tubulin.

Involvement in disease

Ciliary dyskinesia, primary, 28 (CILD28):
A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. Patients may exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-SPAG1 Recombinant Antibody (CBXS-3628)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Recombinant Mouse Anti-SPAG1 Recombinant Antibody (10G1/2) (CAT#: CBMAB-XB1057-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry