Mouse Anti-SPARC Recombinant Antibody (CBXS-2589) (CBMAB-S5345-CQ)

Name: Mouse Anti-SPARC Recombinant Antibody (CBXS-2589)
SKU: CBMAB-S5345-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-2589

Application

FC, IHC, WB

Immunogen

Recombinant protein corresponding to human SPARC

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Concentration

LYOPH

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

SPARC

Introduction

This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

6678

UniProt ID

P09486

Alternative Names

Secreted Protein Acidic And Cysteine Rich; Secreted Protein Acidic And Rich In Cysteine; Basement-Membrane Protein 40; Osteonectin; BM-40; ON; Secreted Protein, Acidic, Cysteine-Rich (Osteonectin); Cysteine-Rich Protein; OI17;

Function

Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca2+ with a low affinity and an EF-hand loop that binds a Ca2+ ion with a high affinity.

Biological Process

Biological Process anatomical structure developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of angiogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of endothelial cell proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of endothelial cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of cell morphogenesisManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Secreted, extracellular space, extracellular matrix, basement membrane
In or around the basement membrane.

Involvement in disease

Osteogenesis imperfecta 17 (OI17):
An autosomal recessive form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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