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SPARC

This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2015]

Full Name

SPARC

Function

Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca2+ with a low affinity and an EF-hand loop that binds a Ca2+ ion with a high affinity.

Biological Process

Biological Process anatomical structure developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of angiogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of endothelial cell proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of endothelial cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of cell morphogenesisManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Secreted, extracellular space, extracellular matrix, basement membrane
In or around the basement membrane.

Involvement in disease

Osteogenesis imperfecta 17 (OI17):
An autosomal recessive form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae.

Anti-SPARC antibodies

Mouse Anti-SPARC Antibody (AON-1) (CBMAB-1615CQ)

SDS

Target: SPARC

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Cattle, Dog, Human, Monkey, Pig, Rabbit, Rat

Clone: AON-1

Application*: E, IF, IH, IP, WB

Mouse Anti-SPARC Recombinant Antibody (CBXS-2694) (CBMAB-S5446-CQ)

SDS

Target: SPARC

Host: Mouse

Specificity: Human

Clone: CBXS-2694

Application*: E, WB

Mouse Anti-SPARC Recombinant Antibody (CBXS-2667) (CBMAB-S5419-CQ)

SDS

Target: SPARC

Host: Mouse

Specificity: Human

Clone: CBXS-2667

Application*: E, WB

Rat Anti-SPARC Recombinant Antibody (CBXS-2590) (CBMAB-S5346-CQ)

SDS

Target: SPARC

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: CBXS-2590

Application*: E, IH

Mouse Anti-SPARC Recombinant Antibody (CBXS-2589) (CBMAB-S5345-CQ)

SDS

Target: SPARC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-2589

Application*: F, IH, WB

Mouse Anti-SPARC Recombinant Antibody (CBXS-0682) (CBMAB-S3619-CQ)

SDS

Target: SPARC

Host: Mouse

Specificity: Rat

Clone: CBXS-0682

Application*: WB, IC, P, C, E

Mouse Anti-SPARC Recombinant Antibody (CBXS-0681) (CBMAB-S3618-CQ)

SDS

Target: SPARC

Host: Mouse

Specificity: Human

Clone: CBXS-0681

Application*: WB, IC, P, C, E

Rabbit Anti-SPARC Recombinant Antibody (CBXS-5327) (CBMAB-S2541-CQ)

SDS

Target: SPARC

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: CBXS-5327

Application*: WB, P

Mouse Anti-SPARC Recombinant Antibody (CBXS-4008) (CBMAB-S1269-CQ)

SDS

Target: SPARC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-4008

Application*: WB

Mouse Anti-SPARC Recombinant Antibody (CBXS-3803) (CBMAB-S1074-CQ)

SDS

Target: SPARC

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXS-3803

Application*: E, WB

Mouse Anti-SPARC Recombinant Antibody (CBXS-5941) (CBMAB-S0790-CQ)

SDS

Target: SPARC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-5941

Application*: IH, WB

Mouse Anti-SPARC Recombinant Antibody (CBXS-5784) (CBMAB-S0642-CQ)

SDS

Target: SPARC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-5784

Application*: WB

Rat Anti-SPARC Recombinant Antibody (CBXS-5762) (CBMAB-S0622-CQ)

SDS

Target: SPARC

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: CBXS-5762

Application*: E, IH

Mouse Anti-SPARC Recombinant Antibody (CBXS-5714) (CBMAB-S0581-CQ)

SDS

Target: SPARC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Cattle, Human, Rat

Clone: CBXS-5714

Application*: E, IH, R, WB

Rat Anti-SPARC Recombinant Antibody (CBXS-1667) (CBMAB-S0093-CQ)

SDS

Target: SPARC

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: CBXS-1667

Application*: IS

Mouse Anti-SPARC Recombinant Antibody (CBXS-1665) (CBMAB-S0092-CQ)

SDS

Target: SPARC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-1665

Application*: IS

Rabbit Anti-SPARC Recombinant Antibody (CBXO-0190) (CBMAB-O0853-CQ)

SDS

Target: SPARC

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBXO-0190

Application*: WB, E, IP

Mouse Anti-SPARC Recombinant Antibody (CBXO-0272) (CBMAB-O0852-CQ)

SDS

Target: SPARC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Cattle, Human

Clone: CBXO-0272

Application*: E, WB

Mouse Anti-SPARC Recombinant Antibody (CBXO-0485) (CBMAB-O0851-CQ)

SDS

Target: SPARC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Cattle, Human, Rat

Clone: CBXO-0485

Application*: E, IH, R, WB

Mouse Anti-SPARC Recombinant Antibody (N50) (CBMAB-O0850-CQ)

SDS

Target: SPARC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: N50

Application*: E, WB, P, R

Mouse Anti-SPARC Recombinant Antibody (CBXO-0260) (CBMAB-O0849-CQ)

SDS

Target: SPARC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Cattle, Human

Clone: CBXO-0260

Application*: E, F, IH, WB

Mouse Anti-SPARC Recombinant Antibody (1D6) (CBMAB-O0847-CQ)

SDS

Target: SPARC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1D6

Application*: WB

Mouse Anti-SPARC Recombinant Antibody (2B1) (CBMAB-O0846-CQ)

SDS

Target: SPARC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2B1

Application*: P, WB

Mouse Anti-SPARC Recombinant Antibody (LM2) (CBMAB-O0845-CQ)

SDS

Target: SPARC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: LM2

Application*: F, P, WB

Mouse Anti-SPARC Recombinant Antibody (CBXO-0114) (CBMAB-O0844-CQ)

SDS

Target: SPARC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXO-0114

Application*: E, WB

Mouse Anti-SPARC Recombinant Antibody (CBXO-0545) (CBMAB-O0843-CQ)

SDS

Target: SPARC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXO-0545

Application*: E, IH, R, WB

Mouse Anti-SPARC Recombinant Antibody (ON1-1) (CBMAB-O0842-CQ)

SDS

Target: SPARC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Cattle

Clone: ON1-1

Application*: E, F, IH, WB

Mouse Anti-SPARC (AA 224-251) Recombinant Antibody (CBXO-0111) (CBMAB-O0840-CQ)

SDS

Target: SPARC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXO-0111

Application*: WB

Mouse Anti-SPARC (AA 1-303) Recombinant Antibody (CBXO-0210) (CBMAB-O0837-CQ)

SDS

Target: SPARC

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXO-0210

Application*: E, WB

Mouse Anti-SPARC (AA 1-304) Recombinant Antibody (CBXO-0110) (CBMAB-O0137-CQ)

SDS

Target: SPARC

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXO-0110

Application*: WB

Mouse Anti-SPARC Recombinant Antibody (CBXO-0113) (CBMAB-O0136-CQ)

SDS

Target: SPARC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Cattle

Clone: CBXO-0113

Application*: E, IH, WB

Mouse Anti-SPARC Recombinant Antibody (CBXO-0115) (CBMAB-O0118-CQ)

SDS

Target: SPARC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Cattle

Clone: CBXO-0115

Application*: E, F, IH, WB

Rabbit Anti-SPARC Recombinant Antibody (D10F10) (CBMAB-CP2550-LY)

SDS

Target: SPARC

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: D10F10

Application*: WB, P

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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