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Mouse Anti-SPC25 Recombinant Antibody (CBXS-4409) (CBMAB-S1651-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4409
Antibody Isotype
IgG1
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SPC25, NDC80 Kinetochore Complex Component
Introduction
This gene encodes a protein that may be involved in kinetochore-microtubule interaction and spindle checkpoint activity.
Entrez Gene ID
57405
UniProt ID
Q9HBM1
Alternative Names
SPC25, NDC80 Kinetochore Complex Component; SPBC25; HSpc25; SPC25, NDC80 Kinetochore Complex Component, Homolog (S. Cerevisiae); Spindle Pole Body Component 25 Homolog (S. Cerevisiae); SPC25, NDC80 Kinetochore Complex Component, Homolog;
Function
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14699129, PubMed:14738735).
Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735, PubMed:14699129).
The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).
Biological Process
Biological Process attachment of spindle microtubules to kinetochoreManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process cell divisionIEA:UniProtKB-KW
Biological Process chromosome segregationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mitotic spindle assembly checkpoint signaling1 PublicationIC:ComplexPortal
Biological Process mitotic spindle organizationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Nucleus
Chromosome, centromere, kinetochore
Localizes to kinetochores from late prophase to anaphase (PubMed:14738735).
Localizes specifically to the outer plate of the kinetochore (PubMed:14738735, PubMed:14699129).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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