SPC25
This gene encodes a protein that may be involved in kinetochore-microtubule interaction and spindle checkpoint activity.
Full Name
SPC25, NDC80 Kinetochore Complex Component
Function
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14699129, PubMed:14738735).
Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735, PubMed:14699129).
The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).
Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735, PubMed:14699129).
The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).
Biological Process
Biological Process attachment of spindle microtubules to kinetochoreManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process cell divisionIEA:UniProtKB-KW
Biological Process chromosome segregationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mitotic spindle assembly checkpoint signaling1 PublicationIC:ComplexPortal
Biological Process mitotic spindle organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cell divisionIEA:UniProtKB-KW
Biological Process chromosome segregationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mitotic spindle assembly checkpoint signaling1 PublicationIC:ComplexPortal
Biological Process mitotic spindle organizationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Nucleus
Chromosome, centromere, kinetochore
Localizes to kinetochores from late prophase to anaphase (PubMed:14738735).
Localizes specifically to the outer plate of the kinetochore (PubMed:14738735, PubMed:14699129).
Chromosome, centromere, kinetochore
Localizes to kinetochores from late prophase to anaphase (PubMed:14738735).
Localizes specifically to the outer plate of the kinetochore (PubMed:14738735, PubMed:14699129).
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Anti-SPC25 antibodies
+ Filters
Target: SPC25
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5171
Application*: WB
Target: SPC25
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4834
Application*: WB
Target: SPC25
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4749
Application*: WB
Target: SPC25
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4409
Application*: WB
Target: SPC25
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4139
Application*: WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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