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SPC25

This gene encodes a protein that may be involved in kinetochore-microtubule interaction and spindle checkpoint activity.
Full Name
SPC25, NDC80 Kinetochore Complex Component
Function
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14699129, PubMed:14738735).
Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735, PubMed:14699129).
The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).
Biological Process
Biological Process attachment of spindle microtubules to kinetochoreManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process cell divisionIEA:UniProtKB-KW
Biological Process chromosome segregationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mitotic spindle assembly checkpoint signaling1 PublicationIC:ComplexPortal
Biological Process mitotic spindle organizationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Nucleus
Chromosome, centromere, kinetochore
Localizes to kinetochores from late prophase to anaphase (PubMed:14738735).
Localizes specifically to the outer plate of the kinetochore (PubMed:14738735, PubMed:14699129).
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Anti-SPC25 antibodies

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Mouse Anti-SPC25 Recombinant Antibody (CBXS-5171) (CBMAB-S2389-CQ)

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Target: SPC25
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5171
Application*: WB
Datasheet SDS

Mouse Anti-SPC25 Recombinant Antibody (CBXS-4834) (CBMAB-S2058-CQ)

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Target: SPC25
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4834
Application*: WB
Datasheet SDS

Mouse Anti-SPC25 Recombinant Antibody (CBXS-4749) (CBMAB-S1978-CQ)

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Target: SPC25
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4749
Application*: WB
Datasheet SDS

Mouse Anti-SPC25 Recombinant Antibody (CBXS-4409) (CBMAB-S1651-CQ)

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Target: SPC25
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4409
Application*: WB
Datasheet SDS

Mouse Anti-SPC25 Recombinant Antibody (CBXS-4139) (CBMAB-S1393-CQ)

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Target: SPC25
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4139
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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