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SPC25

This gene encodes a protein that may be involved in kinetochore-microtubule interaction and spindle checkpoint activity.

Full Name

SPC25, NDC80 Kinetochore Complex Component

Function

Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14699129, PubMed:14738735).
Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735, PubMed:14699129).
The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).

Biological Process

Biological Process attachment of spindle microtubules to kinetochoreManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process cell divisionIEA:UniProtKB-KW
Biological Process chromosome segregationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mitotic spindle assembly checkpoint signaling1 PublicationIC:ComplexPortal
Biological Process mitotic spindle organizationManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Nucleus
Chromosome, centromere, kinetochore
Localizes to kinetochores from late prophase to anaphase (PubMed:14738735).
Localizes specifically to the outer plate of the kinetochore (PubMed:14738735, PubMed:14699129).

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Anti-SPC25 antibodies

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Mouse Anti-SPC25 Recombinant Antibody (CBXS-5171) (CBMAB-S2389-CQ)

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Target: SPC25

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-5171

Application*: WB

Mouse Anti-SPC25 Recombinant Antibody (CBXS-4834) (CBMAB-S2058-CQ)

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Target: SPC25

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-4834

Application*: WB

Mouse Anti-SPC25 Recombinant Antibody (CBXS-4749) (CBMAB-S1978-CQ)

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Target: SPC25

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-4749

Application*: WB

Mouse Anti-SPC25 Recombinant Antibody (CBXS-4409) (CBMAB-S1651-CQ)

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Target: SPC25

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-4409

Application*: WB

Mouse Anti-SPC25 Recombinant Antibody (CBXS-4139) (CBMAB-S1393-CQ)

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Target: SPC25

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-4139

Application*: WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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